Featured Research

from universities, journals, and other organizations

Animal model of typhoid fever could lead to better vaccines

Date:
October 25, 2012
Source:
Cell Press
Summary:
The first mouse model of the common bacterial disease typhoid fever is reported in a new study. Because the animals show human-like symptoms and respond positively to immunization, they could be used to develop more effective vaccines against the deadly pathogen.

The first mouse model of the common bacterial disease typhoid fever is reported in a study published by Cell Press October 25 in the journal Cell. Because the animals show human-like symptoms and respond positively to immunization, they could be used to develop more effective vaccines against the deadly pathogen.

"Prior to our work, there was no small animal model for studying immune responses to the bacteria that cause typhoid fever," says study author Matthew Hayden of Columbia University. "We hope that the model we have developed will promote rapid progress in developing better vaccines."

Typhoid fever is characterized by rash and severe diarrhea, and it causes more than 220,000 deaths each year, frequently in developing countries lacking clean sources of drinking water. It is caused by the bacterium Salmonella typhi (S. Typhi), which normally infects humans but not mice. Unlike humans, mice express toll-like receptor 11 (TLR11), an immune cell receptor that recognizes molecules found in a range of microbes and triggers immune responses that help to fight infections.

"The two vaccines currently approved for this disease are only modestly effective, so research aimed at improving vaccines is essential," says senior study author Sankar Ghosh of Columbia University.

Because TLR11 is highly expressed in the mouse intestine, Hayden and his colleagues suspected that this receptor might recognize pathogens that cause intestinal diseases and could be responsible for preventing typhoid fever in mice. To answer these questions, the researchers inactivated the tlr11 gene in mice and exposed them to S. Typhi. These mice developed severe intestinal tissue damage and hallmark symptoms such as fever and diarrhea. But when the mice were first immunized with heat-killed S. Typhi, they mounted strong immune responses and became impervious to infection.

Moreover, the researchers found that the key component responsible for S. Typhi's virulence is a protein called flagellin, which is recognized by TLR11. Because other pathogens have flagellin, these mice might also serve as a model system for other important bacterial diseases. "Having an animal model vastly improves our ability to investigate diseases, the immune response and, importantly, can be immensely beneficial for efforts to develop new vaccines and therapies," Hayden says.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ramkumar Mathur, Hyunju Oh, Dekai Zhang, Sung-Gyoo Park, Jin Seo, Alicia Koblansky, MatthewS. Hayden, Sankar Ghosh. A Mouse Model of Salmonella Typhi Infection. Cell, 2012; 151 (3): 590 DOI: 10.1016/j.cell.2012.08.042

Cite This Page:

Cell Press. "Animal model of typhoid fever could lead to better vaccines." ScienceDaily. ScienceDaily, 25 October 2012. <www.sciencedaily.com/releases/2012/10/121025122222.htm>.
Cell Press. (2012, October 25). Animal model of typhoid fever could lead to better vaccines. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2012/10/121025122222.htm
Cell Press. "Animal model of typhoid fever could lead to better vaccines." ScienceDaily. www.sciencedaily.com/releases/2012/10/121025122222.htm (accessed October 1, 2014).

Share This



More Plants & Animals News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Dolphins Might Use Earth's Magnetic Field As A GPS

Dolphins Might Use Earth's Magnetic Field As A GPS

Newsy (Sep. 30, 2014) A study released Monday suggests dolphins might be able to sense the Earth's magnetic field and possibly use it as a means of navigation. Video provided by Newsy
Powered by NewsLook.com
How To Battle Stink Bug Season

How To Battle Stink Bug Season

Newsy (Sep. 30, 2014) Homeowners in 33 states grapple with stink bugs moving indoors at this time of year. Here are a few tips to avoid stink bug infestations. Video provided by Newsy
Powered by NewsLook.com
California University Designs Sustainable Winery

California University Designs Sustainable Winery

Reuters - US Online Video (Sep. 27, 2014) Amid California's worst drought in decades, scientists at UC Davis design a sustainable winery that includes a water recycling system. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins