Featured Research

from universities, journals, and other organizations

Animal model of typhoid fever could lead to better vaccines

Date:
October 25, 2012
Source:
Cell Press
Summary:
The first mouse model of the common bacterial disease typhoid fever is reported in a new study. Because the animals show human-like symptoms and respond positively to immunization, they could be used to develop more effective vaccines against the deadly pathogen.

The first mouse model of the common bacterial disease typhoid fever is reported in a study published by Cell Press October 25 in the journal Cell. Because the animals show human-like symptoms and respond positively to immunization, they could be used to develop more effective vaccines against the deadly pathogen.

"Prior to our work, there was no small animal model for studying immune responses to the bacteria that cause typhoid fever," says study author Matthew Hayden of Columbia University. "We hope that the model we have developed will promote rapid progress in developing better vaccines."

Typhoid fever is characterized by rash and severe diarrhea, and it causes more than 220,000 deaths each year, frequently in developing countries lacking clean sources of drinking water. It is caused by the bacterium Salmonella typhi (S. Typhi), which normally infects humans but not mice. Unlike humans, mice express toll-like receptor 11 (TLR11), an immune cell receptor that recognizes molecules found in a range of microbes and triggers immune responses that help to fight infections.

"The two vaccines currently approved for this disease are only modestly effective, so research aimed at improving vaccines is essential," says senior study author Sankar Ghosh of Columbia University.

Because TLR11 is highly expressed in the mouse intestine, Hayden and his colleagues suspected that this receptor might recognize pathogens that cause intestinal diseases and could be responsible for preventing typhoid fever in mice. To answer these questions, the researchers inactivated the tlr11 gene in mice and exposed them to S. Typhi. These mice developed severe intestinal tissue damage and hallmark symptoms such as fever and diarrhea. But when the mice were first immunized with heat-killed S. Typhi, they mounted strong immune responses and became impervious to infection.

Moreover, the researchers found that the key component responsible for S. Typhi's virulence is a protein called flagellin, which is recognized by TLR11. Because other pathogens have flagellin, these mice might also serve as a model system for other important bacterial diseases. "Having an animal model vastly improves our ability to investigate diseases, the immune response and, importantly, can be immensely beneficial for efforts to develop new vaccines and therapies," Hayden says.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ramkumar Mathur, Hyunju Oh, Dekai Zhang, Sung-Gyoo Park, Jin Seo, Alicia Koblansky, MatthewS. Hayden, Sankar Ghosh. A Mouse Model of Salmonella Typhi Infection. Cell, 2012; 151 (3): 590 DOI: 10.1016/j.cell.2012.08.042

Cite This Page:

Cell Press. "Animal model of typhoid fever could lead to better vaccines." ScienceDaily. ScienceDaily, 25 October 2012. <www.sciencedaily.com/releases/2012/10/121025122222.htm>.
Cell Press. (2012, October 25). Animal model of typhoid fever could lead to better vaccines. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/10/121025122222.htm
Cell Press. "Animal model of typhoid fever could lead to better vaccines." ScienceDaily. www.sciencedaily.com/releases/2012/10/121025122222.htm (accessed April 18, 2014).

Share This



More Plants & Animals News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Vermont Goat Meat Gives Refugees Taste of Home

Vermont Goat Meat Gives Refugees Taste of Home

AP (Apr. 18, 2014) Dairy farmers and ethnic groups in Vermont are both benefiting from a unique collaborative effort that's feeding a growing need for fresh and affordable goat meat. (April 18) Video provided by AP
Powered by NewsLook.com
The Great British Farmland Boom

The Great British Farmland Boom

Reuters - Business Video Online (Apr. 17, 2014) Britain's troubled Co-operative Group is preparing to cash in on nearly 18,000 acres of farmland in one of the biggest UK land sales in decades. As Ivor Bennett reports, the market timing couldn't be better, with farmland prices soaring over 270 percent in the last 10 years. Video provided by Reuters
Powered by NewsLook.com
Flamingo Frenzy Ahead of Zoo Construction

Flamingo Frenzy Ahead of Zoo Construction

AP (Apr. 17, 2014) With plenty of honking, flapping, and fluttering, more than three dozen Caribbean flamingos at Zoo Miami were rounded up today as the iconic exhibit was closed for renovations. (April 17) Video provided by AP
Powered by NewsLook.com
Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins