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Sorting stem cells: Scientists propose a new way to isolate early stage embryonic stem cells

Date:
January 3, 2013
Source:
American Institute of Physics (AIP)
Summary:
When an embryonic stem cell is in the first stage of its development it has the potential to grow into any type of cell in the body, a state scientists call undifferentiated. Using an electric field to pull stem cells through a fluid, a team of researchers from Scotland has now demonstrated a way to easily distinguish undifferentiated embryonic stem cells from later-stage stem cells whose fate is sealed.

When an embryonic stem cell is in the first stage of its development it has the potential to grow into any type of cell in the body, a state scientists call undifferentiated. A team of researchers from Scotland has now demonstrated a way to easily distinguish undifferentiated embryonic stem cells from later-stage stem cells whose fate is sealed.

The results are published in the American Institute of Physics' (AIP) journal Biomicrofluidics.

The researchers used an electric field to pull stem cells through a fluid in a process called dielectrophoresis. They varied the frequency of the voltage used to generate the electric field and studied how the cells moved, a response that was affected by the cell's electrical properties. The researchers found that differentiated stem cells could store a significantly greater charge on their outer membranes, a characteristic that might be used to effectively identify and separate them from undifferentiated cells.

The researchers write that the wrinkling, folding, and thinning of a cell's membrane as it differentiates may explain why the later-stage cells can store more charge. The sorting method may prove useful in separating cells for biomedical research or ultimately for treatments of diseases such as Parkinson's.


Story Source:

The above story is based on materials provided by American Institute of Physics (AIP). Note: Materials may be edited for content and length.


Journal Reference:

  1. Srinivas Velugotla, Steve Pells, Heidi K. Mjoseng, Cairnan R. E. Duffy, Stewart Smith, Paul De Sousa, Ronald Pethig. Dielectrophoresis based discrimination of human embryonic stem cells from differentiating derivatives. Biomicrofluidics, 2012; 6 (4): 044113 DOI: 10.1063/1.4771316

Cite This Page:

American Institute of Physics (AIP). "Sorting stem cells: Scientists propose a new way to isolate early stage embryonic stem cells." ScienceDaily. ScienceDaily, 3 January 2013. <www.sciencedaily.com/releases/2013/01/130103130758.htm>.
American Institute of Physics (AIP). (2013, January 3). Sorting stem cells: Scientists propose a new way to isolate early stage embryonic stem cells. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2013/01/130103130758.htm
American Institute of Physics (AIP). "Sorting stem cells: Scientists propose a new way to isolate early stage embryonic stem cells." ScienceDaily. www.sciencedaily.com/releases/2013/01/130103130758.htm (accessed April 20, 2014).

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