Featured Research

from universities, journals, and other organizations

Protein analysis: Understanding flexibility and how different parts move

Date:
March 5, 2013
Source:
Sissa Medialab
Summary:
Scientists have published a review on an innovative instrument for protein analysis. In order to understand how a protein works one may analyze its chemical composition or observe its shape. However, a new way to study proteins is to observe their flexibility and how their different parts move.

Cristian Micheletti, a scientist of the International School for Advanced Studies of Trieste (SISSA), has published in Physics of Life Reviews a review on an innovative instrument for protein analysis.

In order to understand how a protein works one may analyze its chemical composition or observe its shape. However, a brand new way to study proteins is to observe their flexibility and how their different parts move. Cristian Micheletti of SISSA, a pioneer scientist in this kind of research, has just published a systematic revision of all literature concerned with such new and promising field of research, which reveals the great potentialities of such an innovative methodology.

Proteins are molecules that within a living organism perform a vast array of roles that are fundamental for its survival. Scientists study them, for instance, observing their composition and unveiling their chemical sequence (the chain of amino acids a protein is composed of.) Another approach tries instead to define the three-dimensional structure of proteins, which is fundamental to understand their functions. All these analyses are usually carried out through comparative methods comparing various molecules. A new frontier today is represented by the studies exploring the “internal dynamics” of proteins, that is to say the way they fold and change shape.

“Let’s envisage a pair of scissors, an object which performs a precise function. We may analyze the material they are made of, which will give us indications on their use. We may then observe its shape, which will provide further information. We may finally observe how the different parts they are composed of move, so that we may at last gain a comprehensive overview  of their function”, explains Micheletti. “This is what we are doing with our group at SISSA: we observe how the units forming proteins move and we try to develop the comparative analysis instruments that may be useful to the entire scientific community.”

Micheletti and his research group have been among the first to work in that respect and are an authoritative voice in the field, so much that the Physics of Life Reviews has chosen to ask the scientist himself this review.

“Our research will definitely not end here”, clarifies Micheletti. “We are actually working to improve the analysis techniques. Such review, however, will be a thorough outline of the state of the art that will guide us and also all those who are working in this field today.”


Story Source:

The above story is based on materials provided by Sissa Medialab. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cristian Micheletti. Comparing proteins by their internal dynamics: Exploring structure–function relationships beyond static structural alignments. Physics of Life Reviews, 2012; DOI: 10.1016/j.plrev.2012.10.009

Cite This Page:

Sissa Medialab. "Protein analysis: Understanding flexibility and how different parts move." ScienceDaily. ScienceDaily, 5 March 2013. <www.sciencedaily.com/releases/2013/03/130305080659.htm>.
Sissa Medialab. (2013, March 5). Protein analysis: Understanding flexibility and how different parts move. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/03/130305080659.htm
Sissa Medialab. "Protein analysis: Understanding flexibility and how different parts move." ScienceDaily. www.sciencedaily.com/releases/2013/03/130305080659.htm (accessed October 22, 2014).

Share This



More Matter & Energy News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Chameleon Camouflage to Give Tanks Cloaking Capabilities

Chameleon Camouflage to Give Tanks Cloaking Capabilities

Reuters - Innovations Video Online (Oct. 22, 2014) — Inspired by the way a chameleon changes its colour to disguise itself; scientists in Poland want to replace traditional camouflage paint with thousands of electrochromic plates that will continuously change colour to blend with its surroundings. The first PL-01 concept tank prototype will be tested within a few years, with scientists predicting that a similar technology could even be woven into the fabric of a soldiers' clothing making them virtually invisible to the naked eye. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Jet Sales Lift Boeing Profit 18 Pct.

Jet Sales Lift Boeing Profit 18 Pct.

Reuters - Business Video Online (Oct. 22, 2014) — Strong jet demand has pushed Boeing to raise its profit forecast for the third time, but analysts were disappointed by its small cash flow. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Internet of Things Aims to Smarten Your Life

Internet of Things Aims to Smarten Your Life

AP (Oct. 22, 2014) — As more and more Bluetooth-enabled devices are reaching consumers, developers are busy connecting them together as part of the Internet of Things. (Oct. 22) Video provided by AP
Powered by NewsLook.com
What Is Magic Leap, And Why Is It Worth $500M?

What Is Magic Leap, And Why Is It Worth $500M?

Newsy (Oct. 22, 2014) — Magic Leap isn't publicizing much more than a description of its product, but it’s been enough for Google and others to invest more than $500M. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins