Featured Research

from universities, journals, and other organizations

New approach to battling tuberculosis

Date:
June 18, 2013
Source:
University of Medicine and Dentistry of New Jersey (UMDNJ)
Summary:
Scientists have discovered a drug that cripples tuberculosis bacteria (Mycobacterium tuberculosis) in a novel way, by dissolving the protecting fatty coating of the bacteria. The drug killed the bacterium in culture without the emergence of drug resistance.

Most humans would like to shed their fatty exteriors, but tuberculosis (TB)-causing bacteria rely on theirs for survival. Scientists at the University of Medicine and Dentistry of New Jersey (UMDNJ)-New Jersey Medical School have now discovered a drug that cripples the TB bug by dissolving its protective fatty coating, a finding that could eventually be used to improve TB treatment in humans. The study has been posted online by Nature Chemical Biology.

Related Articles


TB is caused by infection with the bacterium Mycobacterium tuberculosis (Mtb) and is the second biggest cause of death worldwide, second only to HIV/AIDS. And with drug-resistant strains of Mtb on the rise, there is a critical need for more effective anti-TB agents.

"Mtb is a little ball of soap," says lead author David Alland, MD, a professor of medicine and Director of the Center for Emerging and Re-emerging Pathogens at New Jersey Medical School, describing the meshwork of long fatty acids that make up the bug's protective cell wall. There are a few anti-TB drugs that disrupt this coat, but so far no single drug has been able to kill the bacteria completely. So his group went in search of new and better drugs by using a simple and rapid approach. They screened for agents that trigger expression of a bacterial gene that gets turned on when cell wall synthesis is compromised.

They discovered a class of compound called thiophenes that killed the Mtb in culture without the emergence of drug resistance. And the combination of thiophene and the existing coat-busting drug isoniazid achieved 100% bacterial killing. Thiophenes worked by crippling an enzyme called Pks13 that hitches two long fatty acids together to create the bug's fatty coat. With additional information on the molecular structure of these drugs bound to Pks13, Alland hopes to discover ways to tweak the compounds to make them even more potent and less toxic.


Story Source:

The above story is based on materials provided by University of Medicine and Dentistry of New Jersey (UMDNJ). Note: Materials may be edited for content and length.


Journal Reference:

  1. Regina Wilson, Pradeep Kumar, Vijay Parashar, Catherine Vilchθze, Romain Veyron-Churlet, Joel S Freundlich, S Whitney Barnes, John R Walker, Michael J Szymonifka, Emily Marchiano, Shubhada Shenai, Roberto Colangeli, William R Jacobs, Matthew B Neiditch, Laurent Kremer, David Alland. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nature Chemical Biology, 2013; DOI: 10.1038/nchembio.1277

Cite This Page:

University of Medicine and Dentistry of New Jersey (UMDNJ). "New approach to battling tuberculosis." ScienceDaily. ScienceDaily, 18 June 2013. <www.sciencedaily.com/releases/2013/06/130618113654.htm>.
University of Medicine and Dentistry of New Jersey (UMDNJ). (2013, June 18). New approach to battling tuberculosis. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2013/06/130618113654.htm
University of Medicine and Dentistry of New Jersey (UMDNJ). "New approach to battling tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2013/06/130618113654.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) — Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) — As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) — A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Shoveling Snow: How to Prevent Back Injuries

Shoveling Snow: How to Prevent Back Injuries

Washington Post (Jan. 26, 2015) — What&apos;s the proper technique for shoveling snow? A physical therapist offers specific tips for protecting your back while you dig out this winter. Video provided by Washington Post
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins