Featured Research

from universities, journals, and other organizations

Genetic 'off switch' linked to increased risk factors for heart disease

Date:
June 19, 2013
Source:
American Heart Association
Summary:
Risk of heart and blood vessel disease may increase when a particular gene is switched off, according to preliminary research.

Risk of heart and blood vessel disease may increase when a particular gene is switched off, according to preliminary research presented at the American Heart Association's Emerging Science Series Webinar.

Related Articles


Two known biomarkers are high blood levels of certain fats -- low-density lipoproteins ("bad" cholesterol) and high triglycerides. Another recognized biomarker is a protein called adiponectin, which is made in fat tissue and helps regulate the process of turning food into energy. At low levels it is associated with increased disease risk.

Researchers examined these biomarkers in relation to a particular gene, called CPT1A in 888 patients from the Genetics of Lipid-Lowering Drugs and Diet Network study. The gene makes a liver enzyme that helps break down fat in food.

They also monitored a biochemical process called methylation that switches off genes. During this process carbon and hydrogen atoms combine to form a compound called a methyl group, which binds to a portion of a gene and turns off its activity.

"Our results open the door to the development of new screening tools and a clearer understanding of the biological mechanisms that underlie heart disease," said Stella Aslibekyan, Ph.D., study lead author and assistant professor at the University of Alabama at Birmingham.

They found that patients who had methyl groups bound to CPT1A had significantly higher triglycerides and low-density lipoprotein levels, and lower adiponectin.

Heart disease is the number one killer among adults in the United States, and researchers are trying to identify individual genetic differences that might increase risk. One way to do this is by studying subtle variations in indicators of disease, or biomarkers, to identify people who are at greatest risk for developing heart disease.

"This is one step on the road to personalized medicine," Aslibekyan said. "In the future, we may be able to screen for methylation of CPT1A to identify at-risk individuals."

Co-authors are Marguerite M. Irvin, Ph.D.; Jin Sha, M.S.; Degui Zhi, Ph.D.; Krista Stanton Thibeault, M.S.; Michael Y. Tsai, M.D., Ph.D.; Paul N. Hopkins, M.D.; Ingrid B. Borecki, Ph.D.; Jose M. Ordovas, Ph.D.; Devin M. Absher, Ph.D.; and Donna K. Arnett, Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Genetic 'off switch' linked to increased risk factors for heart disease." ScienceDaily. ScienceDaily, 19 June 2013. <www.sciencedaily.com/releases/2013/06/130619132409.htm>.
American Heart Association. (2013, June 19). Genetic 'off switch' linked to increased risk factors for heart disease. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2013/06/130619132409.htm
American Heart Association. "Genetic 'off switch' linked to increased risk factors for heart disease." ScienceDaily. www.sciencedaily.com/releases/2013/06/130619132409.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins