Featured Research

from universities, journals, and other organizations

Genetic 'off switch' linked to increased risk factors for heart disease

Date:
June 19, 2013
Source:
American Heart Association
Summary:
Risk of heart and blood vessel disease may increase when a particular gene is switched off, according to preliminary research.

Risk of heart and blood vessel disease may increase when a particular gene is switched off, according to preliminary research presented at the American Heart Association's Emerging Science Series Webinar.

Two known biomarkers are high blood levels of certain fats -- low-density lipoproteins ("bad" cholesterol) and high triglycerides. Another recognized biomarker is a protein called adiponectin, which is made in fat tissue and helps regulate the process of turning food into energy. At low levels it is associated with increased disease risk.

Researchers examined these biomarkers in relation to a particular gene, called CPT1A in 888 patients from the Genetics of Lipid-Lowering Drugs and Diet Network study. The gene makes a liver enzyme that helps break down fat in food.

They also monitored a biochemical process called methylation that switches off genes. During this process carbon and hydrogen atoms combine to form a compound called a methyl group, which binds to a portion of a gene and turns off its activity.

"Our results open the door to the development of new screening tools and a clearer understanding of the biological mechanisms that underlie heart disease," said Stella Aslibekyan, Ph.D., study lead author and assistant professor at the University of Alabama at Birmingham.

They found that patients who had methyl groups bound to CPT1A had significantly higher triglycerides and low-density lipoprotein levels, and lower adiponectin.

Heart disease is the number one killer among adults in the United States, and researchers are trying to identify individual genetic differences that might increase risk. One way to do this is by studying subtle variations in indicators of disease, or biomarkers, to identify people who are at greatest risk for developing heart disease.

"This is one step on the road to personalized medicine," Aslibekyan said. "In the future, we may be able to screen for methylation of CPT1A to identify at-risk individuals."

Co-authors are Marguerite M. Irvin, Ph.D.; Jin Sha, M.S.; Degui Zhi, Ph.D.; Krista Stanton Thibeault, M.S.; Michael Y. Tsai, M.D., Ph.D.; Paul N. Hopkins, M.D.; Ingrid B. Borecki, Ph.D.; Jose M. Ordovas, Ph.D.; Devin M. Absher, Ph.D.; and Donna K. Arnett, Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Genetic 'off switch' linked to increased risk factors for heart disease." ScienceDaily. ScienceDaily, 19 June 2013. <www.sciencedaily.com/releases/2013/06/130619132409.htm>.
American Heart Association. (2013, June 19). Genetic 'off switch' linked to increased risk factors for heart disease. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2013/06/130619132409.htm
American Heart Association. "Genetic 'off switch' linked to increased risk factors for heart disease." ScienceDaily. www.sciencedaily.com/releases/2013/06/130619132409.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins