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Cigarette smoke impacts genes linked to health of heart and lungs

Date:
July 10, 2013
Source:
American Chemical Society
Summary:
New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage. The study suggests that the effects may be especially profound in obese nonsmokers who inhale "sidesteam smoke" from cigarettes smoldering nearby.
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New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage. The study, published in ACS' Chemical Research in Toxicology, suggests that the effects may be especially profound in obese nonsmokers who inhale "sidesteam smoke" from cigarettes smoldering nearby.

Diana J. Bigelow and colleagues point out that active smoking doubles the risk of heart disease, while second-hand smoke exposure increases this risk by about one-third. They set out to gain more information on why the risks are especially high among people with obesity, using specially fed laboratory mice that are stand-ins for humans in such experiments.

The report describes how mainstream smoke and to a greater extent, sidestream smoke, inhibit the activity of genes that protect the heart and lungs, and activate genes associated with an increased risk of heart disease. Those changes were more profound in obese mice than normal-weight mice. "The present study is the first, to our knowledge, that addresses the in vivo transcriptional response of the heart to cigarette smoke exposure in the setting of high fat diet and obesity, and thus takes a first step toward identifying the molecular basis of adaptive responses that may lead to an increased risk of heart disease in obese smokers," the report states.

The authors acknowledge funding from the Exposure Biology Program in the National Institute of Environmental Health Sciences, part of the National Institutes of Health.


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The above post is reprinted from materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Susan C. Tilton, Norman J. Karin, Bobbie-Jo M. Webb-Robertson, Katrina M. Waters, Vladimir Mikheev, K. Monica Lee, Richard A. Corley, Joel G. Pounds, Diana J. Bigelow. Impaired Transcriptional Response of the Murine Heart to Cigarette Smoke in the Setting of High Fat Diet and Obesity. Chemical Research in Toxicology, 2013; 130620143559006 DOI: 10.1021/tx400078b

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American Chemical Society. "Cigarette smoke impacts genes linked to health of heart and lungs." ScienceDaily. ScienceDaily, 10 July 2013. <www.sciencedaily.com/releases/2013/07/130710114442.htm>.
American Chemical Society. (2013, July 10). Cigarette smoke impacts genes linked to health of heart and lungs. ScienceDaily. Retrieved August 31, 2015 from www.sciencedaily.com/releases/2013/07/130710114442.htm
American Chemical Society. "Cigarette smoke impacts genes linked to health of heart and lungs." ScienceDaily. www.sciencedaily.com/releases/2013/07/130710114442.htm (accessed August 31, 2015).

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