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Tissue loss triggers regeneration in planarian flatworms

Date:
September 3, 2013
Source:
Whitehead Institute for Biomedical Research
Summary:
By investigating regeneration in planarian flatworms, researchers have identified a mechanism -- involving the interplay of two wound-induced genes -- by which the animal can distinguish between wounds that require regeneration and those that do not. Because the genes identified in this study have homologs with conserved functions in most animals, this finding may provide insight into regeneration in other animals, including humans.

Unlike humans, planarian flatworms have the remarkable ability to regrow any missing body part, making them an ideal model with which to study the molecular basis of regeneration.
Credit: Image courtesy of Whitehead Institute for Biomedical Research

Unlike humans, planarian flatworms have the remarkable ability to regrow any missing body part, making them an ideal model with which to study the molecular basis of regeneration.

Over the years scientists have learned that planarians mount recovery responses that differ depending on the severity of the injury they suffer. For example, a worm with a cut or a puncture wound reacts at the cellular and molecular levels quite differently from one that loses its head or tail. What has remained unclear, however, is just exactly how these responses are triggered.

Whitehead Institute Member Peter Reddien and two of his former graduate students, Michael Gaviño and Danielle Wenemoser, address this longstanding question this week in the journal eLife, revealing a fascinating interplay of signals between two wound-induced genes.

According to the work of Gavino, Wenemoser, and Reddien, regeneration initiation in planarians is regulated by the expression of the genes Smed-follistatin (or fst) and Smed-activin-1 and -2 (or act-1 and act-2), that together act like a switch. After a planarian is wounded, the type of injury determines the level fst expression -- -- the more extreme the loss of tissue, the higher the level of fst expressed. At puncture wounds, fst expression is low, and regeneration is inhibited. However, following amputation, which results in major loss of tissue, fst levels rise and in turn inhibit Activin proteins, allowing regeneration to begin.

To the researchers' surprise, this interaction only affects regeneration and healing related to injury. Normal maintenance and cell turnover throughout the planarian body continue unaffected when fst is inhibited, even though these activities rely on the same neoblast cell population that creates new tissue during regeneration.

"It's a really great phenotype," says Reddien, who is also a Howard Hughes Medical Institute Early Career Scientist and an associate professor of biology at Massachusetts Institute of Technology. "It's one of the dream phenotypes -- to have a defect that's regeneration-specific, where the neoblasts are working. It's just regeneration that isn't working."

Such a phenotype could be a powerful tool in the further exploration of mechanisms that control regeneration. And many questions about these mechanisms remain.

"For example, the animals know how far to grow in regeneration, so they don't make tumorous outgrowths," says Wenemoser, who is now a postdoctoral researcher at Stanford University. "There's some kind of regulation on homeostatic size, so they're not growing out all wild and crazy. There's definitely more to investigate there."

Gaviño agrees, and points out that the fst/act-1/2 switch may ultimately help scientists tease apart regeneration in other organisms, including humans.

"This regulation by activin and follistatin may be conserved in other systems," says Gaviño, who is currently a postdoctoral researcher at Univeristy of California, San Francisco. "There are a lot of hints in the scientific literature that versions of activin or follistatin or both are activated by injury and may play a role in regeneration in other animals, but pinning the role of initiating regeneration to them hasn't happened yet."

This work was supported by the National Institutes of Health grant R01GM080639 and the Keck Foundation.


Story Source:

The above story is based on materials provided by Whitehead Institute for Biomedical Research. The original article was written by Nicole Giese Rura. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael A. Gaviño, Danielle Wenemoser, Irving E. Wang, and Peter Reddien. Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling. eLife, September 10, 2013

Cite This Page:

Whitehead Institute for Biomedical Research. "Tissue loss triggers regeneration in planarian flatworms." ScienceDaily. ScienceDaily, 3 September 2013. <www.sciencedaily.com/releases/2013/09/130903091548.htm>.
Whitehead Institute for Biomedical Research. (2013, September 3). Tissue loss triggers regeneration in planarian flatworms. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/09/130903091548.htm
Whitehead Institute for Biomedical Research. "Tissue loss triggers regeneration in planarian flatworms." ScienceDaily. www.sciencedaily.com/releases/2013/09/130903091548.htm (accessed October 22, 2014).

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