Featured Research

from universities, journals, and other organizations

Compound derived from vegetables shields rodents from lethal radiation doses

Date:
October 14, 2013
Source:
Georgetown University Medical Center
Summary:
Researchers say a compound derived from cruciferous vegetable such as cabbage, cauliflower and broccoli protected rats and mice from lethal doses of radiation. Their study suggests the compound, already shown to be safe for humans, may protect normal tissues during radiation therapy for cancer treatment and prevent or mitigate sickness caused by radiation exposure.

Georgetown University Medical Center researchers say a compound derived from cruciferous vegetable such as cabbage, cauliflower and broccoli protected rats and mice from lethal doses of radiation.

Related Articles


Their study, published today in the Proceedings of the National Academy of Sciences (PNAS) suggests the compound, already shown to be safe for humans, may protect normal tissues during radiation therapy for cancer treatment and prevent or mitigate sickness caused by radiation exposure.

The compound, known as DIM (3,3'-diindolylmethane), previously has been found to have cancer preventive properties.

"DIM has been studied as a cancer prevention agent for years, but this is the first indication that DIM can also act as a radiation protector," says the study's corresponding author, Eliot Rosen, MD, PhD, of Georgetown Lombardi Comprehensive Cancer Center.

For the study, the researchers irradiated rats with lethal doses of gamma ray radiation. The animals were then treated with a daily injection of DIM for two weeks, starting 10 minutes after the radiation exposure.

The result was stunning, says Rosen, a professor of oncology, biochemistry and cell & molecular biology, and radiation medicine. "All of the untreated rats died, but well over half of the DIM-treated animals remained alive 30 days after the radiation exposure."

Rosen adds that DIM also provided protection whether the first injection was administered 24 hours before or up to 24 hours after radiation exposure.

"We also showed that DIM protects the survival of lethally irradiated mice," Rosen says. In addition, irradiated mice treated with DIM had less reduction in red blood cells, white blood cells and platelets -- side effects often seen in patients undergoing radiation treatment for cancer.

Rosen says this study points to two potential uses of the compound. "DIM could protect normal tissues in patients receiving radiation therapy for cancer, but could also protect individuals from the lethal consequences of a nuclear disaster."


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Fan, Q. Meng, J. Xu, Y. Jiao, L. Zhao, X. Zhang, F. H. Sarkar, M. L. Brown, A. Dritschilo, E. M. Rosen. DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1308206110

Cite This Page:

Georgetown University Medical Center. "Compound derived from vegetables shields rodents from lethal radiation doses." ScienceDaily. ScienceDaily, 14 October 2013. <www.sciencedaily.com/releases/2013/10/131014155741.htm>.
Georgetown University Medical Center. (2013, October 14). Compound derived from vegetables shields rodents from lethal radiation doses. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/10/131014155741.htm
Georgetown University Medical Center. "Compound derived from vegetables shields rodents from lethal radiation doses." ScienceDaily. www.sciencedaily.com/releases/2013/10/131014155741.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins