Featured Research

from universities, journals, and other organizations

Study identifies mechanism that makes ordinary stem cells create tumors

Date:
November 7, 2013
Source:
University of Southern California
Summary:
A new study illustrates how changes in cell signaling can cause ordinary stem cells in the jaw to start forming benign but potentially harmful tumors.

A new study from the Ostrow School of Dentistry of USC published in Cell Stem Cell illustrates how changes in cell signaling can cause ordinary stem cells in the jaw to start forming benign but potentially harmful tumors.

Related Articles


Principal investigator Songtao Shi, professor at the Ostrow School's Center for Craniofacial Molecular Biology, said ossifying fibromas, the tumors focused on in the study, are benign but can grow aggressively and cause progressive enlargement of the jaw.

"The only treatment option for ossifying fibromas is surgical, which leads to major loss of vital tissues and challenging postsurgical reconstruction," Shi said. "Quality of life is largely compromised. Thus, there is an urgent need to understand the underlying mechanism by which stem cells may contribute to the pathophysiology of orofacial benign tumors and to develop target-specific treatment."

Shi and his collaborators uncovered a cellular signaling pathway that converts healthy mesenchymal stem cells in the jaw into ossifying fibroma mesenchymal stem cells (OFMSC), lessening their ability to make healthy bone tissue and greatly increasing the rate at which they multiply. The tumor stem cells display increased signaling activity with TGF-beta (TGF-b), a signaling protein already shown to be heavily tied to other craniofacial malformations.

Epigenetic upregulation -- switching existing but inactive genes "on" -- of the TGF-b cell signaling loop appears to increase the formation of ossifying fibroma tumors. Conversely, suppressing TGF-b signaling seems to quell the tumor's proliferation rate, Shi said.

While there is still much more investigation needed, Shi said he hopes that the findings have shed light on a way to stop the harmful growth of the tumors before risky surgery is needed.

"With an increased understanding of the mechanism of OFMSC, we can induce them to turn into normal jawbone MSC," he said. "But before we can put this into clinical use, more translational research is needed."


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Journal Reference:

  1. Haiyan Qin, Cunye Qu, Takayoshi Yamaza, Ruili Yang, Xia Lin, Xue-Yan Duan, Kentaro Akiyama, Yi Liu, Qunzhou Zhang, Chider Chen, Yibu Chen, HankHeng Qi, Xin-Hua Feng, AnhD. Le, Songtao Shi. Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1/TGF-β/SMAD3 Autocrine Loop. Cell Stem Cell, 2013; 13 (5): 577 DOI: 10.1016/j.stem.2013.08.010

Cite This Page:

University of Southern California. "Study identifies mechanism that makes ordinary stem cells create tumors." ScienceDaily. ScienceDaily, 7 November 2013. <www.sciencedaily.com/releases/2013/11/131107123041.htm>.
University of Southern California. (2013, November 7). Study identifies mechanism that makes ordinary stem cells create tumors. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2013/11/131107123041.htm
University of Southern California. "Study identifies mechanism that makes ordinary stem cells create tumors." ScienceDaily. www.sciencedaily.com/releases/2013/11/131107123041.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins