Featured Research

from universities, journals, and other organizations

Plant oil suppresses viability of human prostate cancer cells

Date:
November 13, 2013
Source:
Society for Experimental Biology and Medicine
Summary:
Geranylgeraniol, found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, may be a new weapon in the arsenal of mevalonate-suppressive isoprenoids with potential synergism in the fight against prostate cancer.

Researchers at Texas Woman's University have shown that a diterpene geranylgeraniol found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, suppressed the viability of human DU145 prostate carcinoma cells via cell cycle arrest at the G1 phase and the initiation of apoptosis. This finding, reported in the November 2013 issue of Experimental Biology and Medicine, supplies recent evidence supporting the tumor-suppressive potential of dietary isoprenoids, a class of phytochemicals encompassing ~55,000 mevalonate-derived secondary metabolites.

"This line of work dates back to the 1980s when the University of Wisconsin groups led by Drs. Charles Elson and Michael Gould discovered the anti-tumor activity of monoterpenes and soon after, sesqui- and di-terpenes." said Dr. Huanbiao Mo, senior author and professor in the Department of Nutrition and Food Sciences. These compounds, widely present in fruits, vegetables and grains, were found to be much more effective in suppressing the growth of tumor cells than that of normal cells. A study by Mo's group in a 2011 issue of Experimental Biology and Medicine (236:604-613) showed that normal fibroblasts are 10-fold more resistant than murine B16 melanoma cells to geranylgeraniol-mediated growth suppression. This tumor-targeted action of isoprenoids was manifested in animal studies showing no toxicity of isoprenoids at tumor-suppressive doses (reviewed by Mo & Elson, Exp Biol Med, 2004, 229:567-85). Previous work also suggested synergistic impact of isoprenoids on tumor growth, a finding remaining to be confirmed in prostate cancer.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor-suppressive activity of geranylgeraniol was accompanied by down-regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth-related proteins such as Ras, nuclear lamins and insulin-like growth factor receptors. Isoprenoid-mediated suppression of HMG CoA reductase in tumors was previously correlated to growth arrest; the latter was attenuated by supplemental mevalonate. "This is the first time that geranylgeraniol was found to suppress HMG CoA reductase in prostate cancer cells," said Dr. Russell DeBose-Boyd, co-author and professor in the Department of Molecular Genetics and Howard Hughes Medical Institute at UTSW.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "This study by Huanbiao Mo and colleagues at the Texas Woman's University and UT Southwestern Medical Center demonstrates that geranylgeraniol causes dose dependent apoptotic death of human prostate carcinoma cells. They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells. Importantly this article suggests that geranylgeraniol deserves further study as a potential therapy for human prostate cancer."


Story Source:

The above story is based on materials provided by Society for Experimental Biology and Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. V. Fernandes, H. Yeganehjoo, R. Katuru, R. A. DeBose-Boyd, L. L. Morris, R. Michon, Z.-L. Yu, H. Mo. Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase. Experimental Biology and Medicine, 2013; 238 (11): 1265 DOI: 10.1177/1535370213492693

Cite This Page:

Society for Experimental Biology and Medicine. "Plant oil suppresses viability of human prostate cancer cells." ScienceDaily. ScienceDaily, 13 November 2013. <www.sciencedaily.com/releases/2013/11/131113162531.htm>.
Society for Experimental Biology and Medicine. (2013, November 13). Plant oil suppresses viability of human prostate cancer cells. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2013/11/131113162531.htm
Society for Experimental Biology and Medicine. "Plant oil suppresses viability of human prostate cancer cells." ScienceDaily. www.sciencedaily.com/releases/2013/11/131113162531.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins