Featured Research

from universities, journals, and other organizations

Plant oil suppresses viability of human prostate cancer cells

Date:
November 13, 2013
Source:
Society for Experimental Biology and Medicine
Summary:
Geranylgeraniol, found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, may be a new weapon in the arsenal of mevalonate-suppressive isoprenoids with potential synergism in the fight against prostate cancer.

Researchers at Texas Woman's University have shown that a diterpene geranylgeraniol found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, suppressed the viability of human DU145 prostate carcinoma cells via cell cycle arrest at the G1 phase and the initiation of apoptosis. This finding, reported in the November 2013 issue of Experimental Biology and Medicine, supplies recent evidence supporting the tumor-suppressive potential of dietary isoprenoids, a class of phytochemicals encompassing ~55,000 mevalonate-derived secondary metabolites.

"This line of work dates back to the 1980s when the University of Wisconsin groups led by Drs. Charles Elson and Michael Gould discovered the anti-tumor activity of monoterpenes and soon after, sesqui- and di-terpenes." said Dr. Huanbiao Mo, senior author and professor in the Department of Nutrition and Food Sciences. These compounds, widely present in fruits, vegetables and grains, were found to be much more effective in suppressing the growth of tumor cells than that of normal cells. A study by Mo's group in a 2011 issue of Experimental Biology and Medicine (236:604-613) showed that normal fibroblasts are 10-fold more resistant than murine B16 melanoma cells to geranylgeraniol-mediated growth suppression. This tumor-targeted action of isoprenoids was manifested in animal studies showing no toxicity of isoprenoids at tumor-suppressive doses (reviewed by Mo & Elson, Exp Biol Med, 2004, 229:567-85). Previous work also suggested synergistic impact of isoprenoids on tumor growth, a finding remaining to be confirmed in prostate cancer.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor-suppressive activity of geranylgeraniol was accompanied by down-regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth-related proteins such as Ras, nuclear lamins and insulin-like growth factor receptors. Isoprenoid-mediated suppression of HMG CoA reductase in tumors was previously correlated to growth arrest; the latter was attenuated by supplemental mevalonate. "This is the first time that geranylgeraniol was found to suppress HMG CoA reductase in prostate cancer cells," said Dr. Russell DeBose-Boyd, co-author and professor in the Department of Molecular Genetics and Howard Hughes Medical Institute at UTSW.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "This study by Huanbiao Mo and colleagues at the Texas Woman's University and UT Southwestern Medical Center demonstrates that geranylgeraniol causes dose dependent apoptotic death of human prostate carcinoma cells. They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells. Importantly this article suggests that geranylgeraniol deserves further study as a potential therapy for human prostate cancer."


Story Source:

The above story is based on materials provided by Society for Experimental Biology and Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. V. Fernandes, H. Yeganehjoo, R. Katuru, R. A. DeBose-Boyd, L. L. Morris, R. Michon, Z.-L. Yu, H. Mo. Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase. Experimental Biology and Medicine, 2013; 238 (11): 1265 DOI: 10.1177/1535370213492693

Cite This Page:

Society for Experimental Biology and Medicine. "Plant oil suppresses viability of human prostate cancer cells." ScienceDaily. ScienceDaily, 13 November 2013. <www.sciencedaily.com/releases/2013/11/131113162531.htm>.
Society for Experimental Biology and Medicine. (2013, November 13). Plant oil suppresses viability of human prostate cancer cells. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/11/131113162531.htm
Society for Experimental Biology and Medicine. "Plant oil suppresses viability of human prostate cancer cells." ScienceDaily. www.sciencedaily.com/releases/2013/11/131113162531.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins