Featured Research

from universities, journals, and other organizations

New vaccine against lung diseases in goats and sheep

Date:
November 20, 2013
Source:
Universiti Putra Malaysia (UPM)
Summary:
An intranasal spray was developed using local isolated bacterium in Malaysia and it was found to provide better protection against infections by Mannheimia haemolytica bacterium than imported vaccines.

Scientists have developed a new vaccine against lung diseases in goats and sheep.
Credit: Image courtesy of Universiti Putra Malaysia (UPM)

An intranasal spray was developed using local isolated bacterium in Malaysia and it was found to provide better protection against infections by Mannheimia haemolytica bacterium than imported vaccines.

Universiti Putra Malaysia has launched a new vaccine against lung or pneumonic diseases in goats and sheep that was developed and patented by its scientists.

The soft launch of "STVac7," the first intranasal spray vaccine for goats and sheep, was officiated by the Deputy Minister of Science, Technology and Innovation, Datuk Dr Abu Bakar Mohamad Diah, in a brief ceremony on 24 Oct., 2013.

The vaccine was developed and tested from 1998 to 2005 by UPM scientists led by Prof Dr Mohd Zamri Saad of the Faculty of Veterinary Medicine. The other scientist involved is Dr Md. Sabri Mohd Yusoff.

The patent for the STVac7 vaccine has been commercialised to Fed Tech Sdn Bhd, for RM4 million and the company has appointed Bio-Angle Vacs Sdn Bhd to manage the production and marketing of the vaccine, said the Vice Chancellor of UPM, Prof Datuk Dr Mohd Fauzi Hj Ramlan, when speaking at the ceremony.

He said he is confident that the vaccine could penetrate the local and foreign market, since in Malaysia alone, there were more than 600,000 goats and sheep at present and the figure is expected to increase to 1 million by 2015, a growth rate of 12.1% as projected by the Veterinary Services Department.

The company's collaboration with UPM would ensure that it would produce the STVac7 vaccines under Good Manufacturing Practices (GMP) since it would be using the facilities at FTU.GMP@Biotech (or FTU), a service centre under the Faculty of Biotechnology and Biomolecular Science of UPM.

Dr Fauzi said FTU which was established in 1999 is now equipped with the facilities for upstream and downstream production of biotechnological products, including packaging and bottling.

The FTU services centre which cost RM14 million to develop, is now serving a horde of local companies like Malaysia Agriculture HighTech, Stella Gen, Johor BioMicrobe, Pascal Biotech, MVP, One Biotech for the development and production of their biotechnology products.

He said Bio-Angle Vacs Sdn Bhd and FTU were currently developing the standard operating procedure (SOP) for the mass production of the STVAC 7 vaccine using the GMP facilities of the service centre as well as product registration before marketing.

"Actual production for the commercialisation of the product with the GMP certification will begin in July 2014 using the Original Equipment Concept," Dr Fauzi said.

Meanwhile, replying to questions, Prof Dr Zamri said the STVac7 is a vaccine against mannheimiosis or respiratory diseases of goats and sheep caused by bacteria.

It was developed and produced using sophisticated recombinant technology which, unlike the imported vaccines, has been demonstrated to provide protection against bacterium infection in the small ruminants like goats and sheep.

"The current available vaccines against this disease are imported vaccines prepared using foreign strains. They are given via intramuscular injections. The vaccines were found to be ineffective and expensive.

"Therefore, STVac7 was developed using local isolated bacterium that was found to be able to provide protection against infections by Mannheimia haemolytica bacterium A2, A7 and A9. This was proven to be better protection," said Prof Zamri who graduated with his Doctor of Veterinary Medicine degree from UPM before obtaining his PhD from Liverpool.

"The product is cheap and effective. If used according to the suggested protocol, it can reduce mortality due to this disease by more than 90%," he added.

Prof Zamri said the pneumonic diseases brought about by the bacterium usually caused a mortality rate of 30% during the rainy season and the goats and sheep farmers could benefit from the STVac7.

"The product itself is ready for the market since laboratory and field tests have been completed," he said, adding that they started their research in 1998 which ended in 2005.

All the research grants were provided by MOSTI.

He also said that the product and technology could be modified to produce vaccines against other diseases of animals and humans.

"In fact, the technology can be further modified to produce test kits for various diseases," he said.


Story Source:

The above story is based on materials provided by Universiti Putra Malaysia (UPM). The original article was written by Noor Eszereen Juferi. Note: Materials may be edited for content and length.


Cite This Page:

Universiti Putra Malaysia (UPM). "New vaccine against lung diseases in goats and sheep." ScienceDaily. ScienceDaily, 20 November 2013. <www.sciencedaily.com/releases/2013/11/131120103450.htm>.
Universiti Putra Malaysia (UPM). (2013, November 20). New vaccine against lung diseases in goats and sheep. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2013/11/131120103450.htm
Universiti Putra Malaysia (UPM). "New vaccine against lung diseases in goats and sheep." ScienceDaily. www.sciencedaily.com/releases/2013/11/131120103450.htm (accessed September 18, 2014).

Share This



More Plants & Animals News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Chimp Violence Study Renews Debate On Why They Kill

Chimp Violence Study Renews Debate On Why They Kill

Newsy (Sep. 17, 2014) The study weighs in on a debate over whether chimps are naturally violent or become that way due to human interference in the environment. Video provided by Newsy
Powered by NewsLook.com
Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Raw: Scientists Examine Colossal Squid

Raw: Scientists Examine Colossal Squid

AP (Sep. 16, 2014) Squid experts in New Zealand thawed and examined an unusual catch on Tuesday: a colossal squid. It was captured in Antarctica's remote Ross Sea in December last year and has been frozen for eight months. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins