Featured Research

from universities, journals, and other organizations

Important clue to how circulatory system is wired

Date:
November 25, 2013
Source:
Karolinska Institutet
Summary:
A new mechanism that regulates the way blood vessels grow and connect to each other has been discovered by an international team of researchers. The knowledge might open up new opportunities for future cancer therapy.

A new mechanism that regulates the way blood vessels grow and connect to each other has been discovered by an international team of researchers at Karolinska Institutet in Sweden, and Heinrich Heine University Düsseldorf, Germany. The knowledge might open up new opportunities for future cancer therapy. The study is published in the scientific journal PNAS.

Related Articles


If stretched out, the blood vessels in a human body would reach more than twice around the Earth. The complex circulatory system nourishes every cell of our body and proper development of new blood vessels is crucial for embryonic development.

In the current study, the scientists demonstrated for the first time that the enzyme glutaredoxin 2 has an essential role during cardiovascular development. Glutaredoxin 2 belongs to a family of enzymes that convey specific signals within cells. In previous studies, the same researchers have shown that glutaredoxin 2 is indispensable for nerve cell survival during embryonic brain development.

To reduce the number of laboratory mice used, the team was running most of their experiments in zebrafish that were genetically modified so that the circulatory system glowed in a green fluorescent colour. As the young zebrafish is completely transparent, the scientists could follow the growth of the fluorescent blood vessels directly under the microscope. When levels of glutaredoxins were reduced, the blood vessels of the zebrafish embryos were growing randomly without establishing a proper circulatory system. The researchers found that glutaredoxin 2 controls a chemical switch in another protein, sirtuin 1, and that this simple modification of a single amino acid is vital for the circulatory system to develop normally

This knowledge is not only essential to better understand development of our circulatory system in general. Growth of new blood vessels, a process called angiogenesis, also plays a crucial role in the pathology of many diseases, including cancer. The ability to promote angiogenesis is a hallmark of cancer, since growing tumours and metastasis are dependent on vessel formation.

"The understanding how blood vessels develop and how this process can be modulated, can provide a new way to fight cancer in the future," says first study author Lars Bräutigam, at the Department of Medical Biochemistry and Biophysics of Karolinska Institutet and also affiliated with the Science for Life Laboratory (SciLifeLab) in Stockholm, Sweden.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lars Bräutigam, Lasse Dahl Ejby Jensen, Gereon Poschmann, Staffan Nyströma, Sarah Bannenberg, Kristian Dreij, Klaudia Lepka, Timour Prozorovsk, Sergio J. Montano, Orhan Aktas, Per Uhlén, Kai Stühler, Yihai Cao, ArneHolmgren, and Carsten Berndt. Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin. Proceedings of the National Academy of Sciences, November 2013

Cite This Page:

Karolinska Institutet. "Important clue to how circulatory system is wired." ScienceDaily. ScienceDaily, 25 November 2013. <www.sciencedaily.com/releases/2013/11/131125164307.htm>.
Karolinska Institutet. (2013, November 25). Important clue to how circulatory system is wired. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2013/11/131125164307.htm
Karolinska Institutet. "Important clue to how circulatory system is wired." ScienceDaily. www.sciencedaily.com/releases/2013/11/131125164307.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) — With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
Obamacare's New Supreme Court Battle

Obamacare's New Supreme Court Battle

Washington Post (Mar. 4, 2015) — The Affordable Care Act is facing another challenge at the Supreme Court in King v. Burwell, which deals with subsidies for health insurance. The case could cut out a major provision of Obamacare, causing the law to unravel. Here’s what you need to know about the case. Video provided by Washington Post
Powered by NewsLook.com
Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) — After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins