Featured Research

from universities, journals, and other organizations

Important clue to how circulatory system is wired

Date:
November 25, 2013
Source:
Karolinska Institutet
Summary:
A new mechanism that regulates the way blood vessels grow and connect to each other has been discovered by an international team of researchers. The knowledge might open up new opportunities for future cancer therapy.

A new mechanism that regulates the way blood vessels grow and connect to each other has been discovered by an international team of researchers at Karolinska Institutet in Sweden, and Heinrich Heine University Düsseldorf, Germany. The knowledge might open up new opportunities for future cancer therapy. The study is published in the scientific journal PNAS.

Related Articles


If stretched out, the blood vessels in a human body would reach more than twice around the Earth. The complex circulatory system nourishes every cell of our body and proper development of new blood vessels is crucial for embryonic development.

In the current study, the scientists demonstrated for the first time that the enzyme glutaredoxin 2 has an essential role during cardiovascular development. Glutaredoxin 2 belongs to a family of enzymes that convey specific signals within cells. In previous studies, the same researchers have shown that glutaredoxin 2 is indispensable for nerve cell survival during embryonic brain development.

To reduce the number of laboratory mice used, the team was running most of their experiments in zebrafish that were genetically modified so that the circulatory system glowed in a green fluorescent colour. As the young zebrafish is completely transparent, the scientists could follow the growth of the fluorescent blood vessels directly under the microscope. When levels of glutaredoxins were reduced, the blood vessels of the zebrafish embryos were growing randomly without establishing a proper circulatory system. The researchers found that glutaredoxin 2 controls a chemical switch in another protein, sirtuin 1, and that this simple modification of a single amino acid is vital for the circulatory system to develop normally

This knowledge is not only essential to better understand development of our circulatory system in general. Growth of new blood vessels, a process called angiogenesis, also plays a crucial role in the pathology of many diseases, including cancer. The ability to promote angiogenesis is a hallmark of cancer, since growing tumours and metastasis are dependent on vessel formation.

"The understanding how blood vessels develop and how this process can be modulated, can provide a new way to fight cancer in the future," says first study author Lars Bräutigam, at the Department of Medical Biochemistry and Biophysics of Karolinska Institutet and also affiliated with the Science for Life Laboratory (SciLifeLab) in Stockholm, Sweden.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lars Bräutigam, Lasse Dahl Ejby Jensen, Gereon Poschmann, Staffan Nyströma, Sarah Bannenberg, Kristian Dreij, Klaudia Lepka, Timour Prozorovsk, Sergio J. Montano, Orhan Aktas, Per Uhlén, Kai Stühler, Yihai Cao, ArneHolmgren, and Carsten Berndt. Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin. Proceedings of the National Academy of Sciences, November 2013

Cite This Page:

Karolinska Institutet. "Important clue to how circulatory system is wired." ScienceDaily. ScienceDaily, 25 November 2013. <www.sciencedaily.com/releases/2013/11/131125164307.htm>.
Karolinska Institutet. (2013, November 25). Important clue to how circulatory system is wired. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/11/131125164307.htm
Karolinska Institutet. "Important clue to how circulatory system is wired." ScienceDaily. www.sciencedaily.com/releases/2013/11/131125164307.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) — A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) — Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins