Featured Research

from universities, journals, and other organizations

New diagnostic protocols for PPID in horses

Date:
December 4, 2013
Source:
Tufts University
Summary:
Equine pituitary pars intermedia dysfunction (PPID) can be detected earlier and more reliably with a new set of guidelines developed by the Equine Endocrinology Group (EEG), a body of leading veterinarians and researchers in the field of equine endocrinology.

Advanced pituitary pars intermedia dysfunction – this horse has developed a long curly haircoat that is referred to as hypertrichosis or hirsutism.
Credit: Equine Endocrinology Group

Equine pituitary pars intermedia dysfunction (PPID) can be detected earlier and more reliably with a new set of guidelines developed by the Equine Endocrinology Group (EEG), a body of leading veterinarians and researchers in the field of equine endocrinology.

Similar to Cushing's disease in humans but affecting a different area of the pituitary gland, PPID is associated with elevated levels of hormones in the blood. Horses with the condition often have a wide range of clinical signs depending on the stage of the disease, from loss of energy to muscle wasting, and the condition is more common in older horses.

The EEG created a set of recommendations in 2011 to help practitioners identify early versus advanced stages of PPID, and their new recommendations adjust and refine testing procedures for a more thorough and accurate approach to diagnosis. Recommendations are based upon published research on PPID.

"Our collective research has shown that horses can often develop this disease earlier in life, yet earlier clinical signs don't always translate into positive test results," said Nicholas Frank, D.V.M, DACVIM, professor and chair of the Department of Clinical Sciences at the Cummings School of Veterinary Medicine at Tufts University and group coordinator for the Equine Endocrinology Group. "As research on PPID advances, we are identifying practical ways to improve early detection and diagnosis."

In addition to Dr. Frank, the Equine Endocrinology Group includes Drs. Frank Andrews (Louisiana State University); Andy Durham (Liphook Equine Hospital); Dianne McFarlane (Oklahoma State University); and Hal Schott (Michigan State University).

While the clinical signs of PPID are the same, the recommendations address changes to the diagnostic process. Previously, horses showing any signs of this disease were recommended to a undergo one of two tests. One test measures levels of resting adrenocorticotropin hormone (ACTH) which is produced and secreted by the pituitary gland. The other is an overnight dexamethasone suppression test (DST) that causes the production of cortisol to decrease in healthy horses, but not those with PPID.

The newly established guidelines retain the recommendation to measure resting ACTH concentrations, but the group has lowered the recommendation for using the DST. Recent research shows that the DST is no better at detecting PPID than other tests, and horse owners have concerns about dexamethasone inducing laminitis, a painful condition affecting the feet that can lead to death.

Instead, the EEG group recommends a thyrotropin-releasing hormone (TRH) stimulation test, which is particularly useful when horses with early PPID have normal resting ACTH concentrations. TRH causes the pituitary gland to release more hormones and ACTH concentrations increase to a higher level in horses with PPID. This test is easily performed on the farm by taking a baseline blood sample, injecting TRH intravenously, and collecting a second blood sample 10 minutes later. At present, the TRH stimulation test should only be used between December and June, which is the only period in which cut-off values have been established. Cut-off values allow veterinarians to interpret results and determine whether the horse suffers from PPID.

For more information on the PPID diagnostic guidelines visit http://sites.tufts.edu/equineendogroup/.


Story Source:

The above story is based on materials provided by Tufts University. Note: Materials may be edited for content and length.


Cite This Page:

Tufts University. "New diagnostic protocols for PPID in horses." ScienceDaily. ScienceDaily, 4 December 2013. <www.sciencedaily.com/releases/2013/12/131204181421.htm>.
Tufts University. (2013, December 4). New diagnostic protocols for PPID in horses. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2013/12/131204181421.htm
Tufts University. "New diagnostic protocols for PPID in horses." ScienceDaily. www.sciencedaily.com/releases/2013/12/131204181421.htm (accessed September 15, 2014).

Share This



More Plants & Animals News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Conservationists Face Uphill PR Battle With New Shark Rules

Conservationists Face Uphill PR Battle With New Shark Rules

Newsy (Sep. 14, 2014) — New conservation measures for shark fishing face an uphill PR battle in the fight to slow shark extinction. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) — A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) — In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com
Spinosaurus Could Be First Semi-Aquatic Dinosaur

Spinosaurus Could Be First Semi-Aquatic Dinosaur

Newsy (Sep. 11, 2014) — New research has shown that the Spinosaurus, the largest carnivorous dinosaur, might have been just as well suited for life in the water as on land. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins