Featured Research

from universities, journals, and other organizations

New diagnostic protocols for PPID in horses

Date:
December 4, 2013
Source:
Tufts University
Summary:
Equine pituitary pars intermedia dysfunction (PPID) can be detected earlier and more reliably with a new set of guidelines developed by the Equine Endocrinology Group (EEG), a body of leading veterinarians and researchers in the field of equine endocrinology.

Advanced pituitary pars intermedia dysfunction – this horse has developed a long curly haircoat that is referred to as hypertrichosis or hirsutism.
Credit: Equine Endocrinology Group

Equine pituitary pars intermedia dysfunction (PPID) can be detected earlier and more reliably with a new set of guidelines developed by the Equine Endocrinology Group (EEG), a body of leading veterinarians and researchers in the field of equine endocrinology.

Similar to Cushing's disease in humans but affecting a different area of the pituitary gland, PPID is associated with elevated levels of hormones in the blood. Horses with the condition often have a wide range of clinical signs depending on the stage of the disease, from loss of energy to muscle wasting, and the condition is more common in older horses.

The EEG created a set of recommendations in 2011 to help practitioners identify early versus advanced stages of PPID, and their new recommendations adjust and refine testing procedures for a more thorough and accurate approach to diagnosis. Recommendations are based upon published research on PPID.

"Our collective research has shown that horses can often develop this disease earlier in life, yet earlier clinical signs don't always translate into positive test results," said Nicholas Frank, D.V.M, DACVIM, professor and chair of the Department of Clinical Sciences at the Cummings School of Veterinary Medicine at Tufts University and group coordinator for the Equine Endocrinology Group. "As research on PPID advances, we are identifying practical ways to improve early detection and diagnosis."

In addition to Dr. Frank, the Equine Endocrinology Group includes Drs. Frank Andrews (Louisiana State University); Andy Durham (Liphook Equine Hospital); Dianne McFarlane (Oklahoma State University); and Hal Schott (Michigan State University).

While the clinical signs of PPID are the same, the recommendations address changes to the diagnostic process. Previously, horses showing any signs of this disease were recommended to a undergo one of two tests. One test measures levels of resting adrenocorticotropin hormone (ACTH) which is produced and secreted by the pituitary gland. The other is an overnight dexamethasone suppression test (DST) that causes the production of cortisol to decrease in healthy horses, but not those with PPID.

The newly established guidelines retain the recommendation to measure resting ACTH concentrations, but the group has lowered the recommendation for using the DST. Recent research shows that the DST is no better at detecting PPID than other tests, and horse owners have concerns about dexamethasone inducing laminitis, a painful condition affecting the feet that can lead to death.

Instead, the EEG group recommends a thyrotropin-releasing hormone (TRH) stimulation test, which is particularly useful when horses with early PPID have normal resting ACTH concentrations. TRH causes the pituitary gland to release more hormones and ACTH concentrations increase to a higher level in horses with PPID. This test is easily performed on the farm by taking a baseline blood sample, injecting TRH intravenously, and collecting a second blood sample 10 minutes later. At present, the TRH stimulation test should only be used between December and June, which is the only period in which cut-off values have been established. Cut-off values allow veterinarians to interpret results and determine whether the horse suffers from PPID.

For more information on the PPID diagnostic guidelines visit http://sites.tufts.edu/equineendogroup/.


Story Source:

The above story is based on materials provided by Tufts University. Note: Materials may be edited for content and length.


Cite This Page:

Tufts University. "New diagnostic protocols for PPID in horses." ScienceDaily. ScienceDaily, 4 December 2013. <www.sciencedaily.com/releases/2013/12/131204181421.htm>.
Tufts University. (2013, December 4). New diagnostic protocols for PPID in horses. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/12/131204181421.htm
Tufts University. "New diagnostic protocols for PPID in horses." ScienceDaily. www.sciencedaily.com/releases/2013/12/131204181421.htm (accessed July 31, 2014).

Share This




More Plants & Animals News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Thousands Flocking to German Crop Circle

Raw: Thousands Flocking to German Crop Circle

AP (July 30, 2014) Thousands of people are trekking to a Bavarian farmer's field to check out a mysterious set of crop circles. (July 30) Video provided by AP
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins