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Novel cancer cell DNA damage repair mechanism unveiled

Date:
December 11, 2013
Source:
VTT Technical Research Centre of Finland
Summary:
Cancer cells have an exceptional ability to repair damage to their DNA caused during uncontrolled cell division. Scientists have now unveiled a novel piece of the puzzle of cancer cell DNA repair mechanisms that explain the mechanistic changes in the genetic code of cancer cells.

Cancer cells have an exceptional ability to repair damage to their DNA caused during uncontrolled cell division. Scientists have now unveiled a novel piece of the puzzle of cancer cell DNA repair mechanisms that explain the mechanistic changes in the genetic code of cancer cells. These findings result from application of the cell microarray screening method developed by Juha Rantala, Senior Scientist at VTT. Research with a material impact on cancer drug development was published in Science magazine on 5 December 2013.

The new findings explain partially why cancer cells, unlike normal cells, fail to die as a result of DNA damaging insults, and how this mechanism causes new genetic mutations in cancer cells. This new information directly benefits cancer research. Now that scientists understand the repair mechanism, they are better equipped to develop drug therapies that specifically target cancerous cells.

The discovered DNA repair mechanism has previously not been described in human or mammalian cells. Cancer cells use the mechanism to repair DNA damage resulting from uncontrolled DNA replication forced by activated oncogenes.

The genes that participate in the DNA repair mechanism were discovered by Juha Rantala, Senior Scientist at VTT, and Thanos Halazonetis, Coordinator of the EU-funded GENICA (Genomic instability in cancer and pre-cancer) project, with the cell microchip screening method developed by Rantala in 2010. Based on gene silencing, the method allows a single microchip to screen the functions of tens of thousands of genes simultaneously.

The research was part of the EU's GENICA project aimed at discovering why the DNA damage sustained by cancer cells in the early stages of the disease fails to result in the programmed cell death associated with normal cells.


Story Source:

The above story is based on materials provided by VTT Technical Research Centre of Finland. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Costantino, S. K. Sotiriou, J. K. Rantala, S. Magin, E. Mladenov, T. Helleday, J. E. Haber, G. Iliakis, O. Kallioniemi, T. D. Halazonetis. Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells. Science, 2013; DOI: 10.1126/science.1243211

Cite This Page:

VTT Technical Research Centre of Finland. "Novel cancer cell DNA damage repair mechanism unveiled." ScienceDaily. ScienceDaily, 11 December 2013. <www.sciencedaily.com/releases/2013/12/131211093836.htm>.
VTT Technical Research Centre of Finland. (2013, December 11). Novel cancer cell DNA damage repair mechanism unveiled. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2013/12/131211093836.htm
VTT Technical Research Centre of Finland. "Novel cancer cell DNA damage repair mechanism unveiled." ScienceDaily. www.sciencedaily.com/releases/2013/12/131211093836.htm (accessed September 17, 2014).

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