Featured Research

from universities, journals, and other organizations

Variety of genetic risk behind bone cancer in dogs

Date:
December 12, 2013
Source:
Uppsala University
Summary:
Bone cancer in dogs is affected by a variety of genetic risk factors. Researchers have discussed these variabilities in a new study. The study demonstrated that each breed has its own risk genes, but these genes converge in common disease mechanisms. Some genes are known cancer genes in humans, while others are completely new discoveries. The researchers also studied one of the risk factors in more detail and found a new regulatory signal that leads to increased gene expression in bone cancer cells from humans.

Osteosarcoma, a type of bone cancer, is a rare but very aggressive form of cancer that primarily affects teenagers. Among some large-sized dog breeds the disease is much more common, but otherwise osteosarcoma in humans and dogs is very similar. In the current study, the researchers compared the genome of sick and healthy dogs from three different breeds to find inherited risk factors for the disease.

"The key is that we find many different risk factors within each breed. We already knew that greyhounds, Rottweilers and Irish wolfhounds are at increased risk of developing bone cancer and our results explain much of the increased risk," said Emma Ivansson, scientist at SciLifeLab and Uppsala University.

The study demonstrated that each breed has its own risk genes, but these genes converge in common disease mechanisms. Some genes are known cancer genes in humans, while others are completely new discoveries. The researchers also studied one of the risk factors in more detail and found a new regulatory signal that leads to increased gene expression in bone cancer cells from humans.

"Our results show that the pathways involved in bone formation and growth are important for the disease. Because of the great similarities between bone cancer in dogs and humans, we believe that our findings may contribute to an increased understanding of how bone cancer develops in humans," said Kerstin Lindblad-Toh, professor at Uppsala University and Co-Director of the SciLifeLab and Director of Vertebrate Genome Biology at the Broad Institute.

The researchers are continuing to study the identified risk factors to understand more about how they affect tumor development and to see whether different risk factors respond to different types of treatment.


Story Source:

The above story is based on materials provided by Uppsala University. The original article was written by Anneli Waara. Note: Materials may be edited for content and length.


Cite This Page:

Uppsala University. "Variety of genetic risk behind bone cancer in dogs." ScienceDaily. ScienceDaily, 12 December 2013. <www.sciencedaily.com/releases/2013/12/131212100148.htm>.
Uppsala University. (2013, December 12). Variety of genetic risk behind bone cancer in dogs. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/12/131212100148.htm
Uppsala University. "Variety of genetic risk behind bone cancer in dogs." ScienceDaily. www.sciencedaily.com/releases/2013/12/131212100148.htm (accessed July 24, 2014).

Share This




More Plants & Animals News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Dogs Appear To Become Jealous Of Owners' Attention

Dogs Appear To Become Jealous Of Owners' Attention

Newsy (July 23, 2014) A U.C. San Diego researcher says jealousy isn't just a human trait, and dogs aren't the best at sharing the attention of humans with other dogs. Video provided by Newsy
Powered by NewsLook.com
Professor Creates Site Revealing Where People's Cats Live

Professor Creates Site Revealing Where People's Cats Live

Newsy (July 23, 2014) ​It's called I Know Where Your Cat Lives, and you can keep hitting the "Random Cat" button to find more real cats all over the world. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins