Featured Research

from universities, journals, and other organizations

Cell division discovery could offer fresh insight into cancer

Date:
January 14, 2014
Source:
University of Edinburgh
Summary:
New findings on how the cells in our bodies are able to renew themselves could aid our understanding of health disorders, including cancer.

New findings on how the cells in our bodies are able to renew themselves could aid our understanding of health disorders, including cancer.

Scientists have explained a key part of the process of cell division, by which cells are able to keep our organs functioning properly.

They discovered a set of proteins that stabilise the sequence of events in which cells duplicate their DNA and then separate into two new cells, each identical to the original. Flaws in this delicate, complex operation can lead to cancer.

The findings help explain a fundamental process in all living things, in which cells must continually divide to keep the organism alive and well.

Researchers at the University of Edinburgh found that a set of proteins, known as the Ska complex, help anchor DNA, the form of chromosomes, by interacting with strands of cell material. Chromosomes remain attached to these strands as they are separated, in a process that helps distribute DNA correctly to the newly formed cells.

Scientists determined the structure of the relevant part of the protein complex by analysing crystals of it with lab tools and cell-based experiments. This showed how the Ska complex attaches to the strands, helping to bind the DNA material.

The study, published in Nature Communications, was carried out in collaboration with the University of Basel, Technische Universitδt Berlin, and the National Institute of Immunology in New Delhi and funded by the Wellcome Trust.

Dr JP Arulanandam, of the University of Edinburgh's School of Biological Sciences, who led the work, said: "Our findings represent a milestone in resolving the mystery of how these key proteins enable new cells to separate properly and equally, in this essential process for life. The findings of our work have the potential to create new avenues in drug discovery towards fighting cancer."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maria Alba Abad, Bethan Medina, Anna Santamaria, Juan Zou, Carla Plasberg-Hill, Arumugam Madhumalar, Uma Jayachandran, Patrick Marc Redli, Juri Rappsilber, Erich A. Nigg, A. Arockia Jeyaprakash. Structural basis for microtubule recognition by the human kinetochore Ska complex. Nature Communications, 2014; 5 DOI: 10.1038/ncomms3964

Cite This Page:

University of Edinburgh. "Cell division discovery could offer fresh insight into cancer." ScienceDaily. ScienceDaily, 14 January 2014. <www.sciencedaily.com/releases/2014/01/140114103013.htm>.
University of Edinburgh. (2014, January 14). Cell division discovery could offer fresh insight into cancer. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2014/01/140114103013.htm
University of Edinburgh. "Cell division discovery could offer fresh insight into cancer." ScienceDaily. www.sciencedaily.com/releases/2014/01/140114103013.htm (accessed August 1, 2014).

Share This




More Plants & Animals News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pyrenees Orphan Bear Cub Gets Brand New Home

Pyrenees Orphan Bear Cub Gets Brand New Home

AFP (Aug. 1, 2014) — The discovery of a bear cub in the Pyrenees mountains made headlines in April 2014. Despire several attempts to find the animal's mother, the cub remained alone. Now, the Pyrenees Conservation Foundation has constructed an enclosure. Duration: 00:31 Video provided by AFP
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) — Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) — Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
Visitors Feel Part of the Pack at Wolf Preserve

Visitors Feel Part of the Pack at Wolf Preserve

AP (July 31, 2014) — Seacrest Wolf Preserve on the northern Florida panhandle allows more than 10,000 visitors each year to get up close and personal with Arctic and British Columbian Wolves. (July 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins