Featured Research

from universities, journals, and other organizations

Internal clock, feeding rhythm set pace of liver

Date:
January 15, 2014
Source:
Ecole Polytechnique Fédérale de Lausanne
Summary:
Living organisms have adapted to the day-night cycle and, in most cases, evolved a "circadian clock" -- that is: an actual cellular metronome -- whose effects are not completely known yet. A scientific team has found that in the case of the liver, the rhythm of protein production and release is dictated by both the organisms' feeding behaviors and their internal clock.

Living organisms have adapted to the day-night cycle and, in most cases, they have evolved a "circadian clock." Its effects are not completely known yet but its functioning has been shown to have important metabolic consequences for the body. Disruption of normal circadian rhythms can have deleterious effects on health; for example lack of sleep is linked with obesity, and the time of feeding was shown to affect the ability to control body weight.

Scientists from the Nestlé Institute of Health Sciences (NIHS) and the École polytechnique fédérale de Lausanne (EPFL), supported by a 2012 grant from the Swiss Leenaards Foundation originally awarded to the Université de Lausanne, have found that in the case of the liver, the rhythm of protein production and release is dictated by both the organisms' feeding behaviors and their internal clock. The current study was published last week in the journal Proceedings of the National Academy of Science of the USA (PNAS).

The researchers, under the direction of Frédéric Gachon (NIHS) and Felix Naef (EPFL), analyzed liver proteins with mass spectrometry, one of the new analytical tools currently available that allow a closer inspection of the real impact of this clock on some biological processes, in particular at a level of temporal protein abundance. They measured the concentration of more than 5000 different proteins -- whereas previous techniques only allowed the identification a few hundreds at best.

The results suggest that the circadian clock does not only influence the production of proteins by the genes, but also the way the liver regulated the storage and release of proteins into the body. "Our experiments seem to prove that the pace set by feeding patterns takes precedence over the circadian rhythm. However, it appears that the strongest effect takes place when these two rhythms overlap," said Frédéric Gachon.

As a next step, this research will attempt to translate some of these results to humans. "Our work will help develop strategies focused on diet to help treat patients suffering from disorders associated to circadian dysfunctions" said Felix Naef.


Story Source:

The above story is based on materials provided by Ecole Polytechnique Fédérale de Lausanne. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Mauvoisin, J. Wang, C. Jouffe, E. Martin, F. Atger, P. Waridel, M. Quadroni, F. Gachon, F. Naef. Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1314066111

Cite This Page:

Ecole Polytechnique Fédérale de Lausanne. "Internal clock, feeding rhythm set pace of liver." ScienceDaily. ScienceDaily, 15 January 2014. <www.sciencedaily.com/releases/2014/01/140115100122.htm>.
Ecole Polytechnique Fédérale de Lausanne. (2014, January 15). Internal clock, feeding rhythm set pace of liver. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/01/140115100122.htm
Ecole Polytechnique Fédérale de Lausanne. "Internal clock, feeding rhythm set pace of liver." ScienceDaily. www.sciencedaily.com/releases/2014/01/140115100122.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins