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Quality control of mitochondria as defense against disease

Date:
January 20, 2014
Source:
EMBO - excellence in life sciences
Summary:
Scientists have discovered that two genes linked to hereditary Parkinson’s disease are involved in the early-stage quality control of mitochondria. The protective mechanism removes damaged proteins that arise from oxidative stress from mitochondria.

Scientists from the Montreal Neurological Institute and Hospital in Canada have discovered that two genes linked to hereditary Parkinson's disease are involved in the early-stage quality control of mitochondria. The protective mechanism, which is reported in The EMBO Journal, removes damaged proteins that arise from oxidative stress from mitochondria.

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"PINK1 and parkin, are implicated in selectively targeting dysfunctional components of mitochondria to the lysosome under conditions of excessive oxidative damage within the organelle," said Edward Fon, Professor at the McGill Parkinson Program at the Montreal Neurological Institute and Hospital. "Our study reveals a quality control mechanism where vesicles bud off from mitochondria and proceed to the lysosome for degradation. This method is distinct from the degradation pathway for damaged whole mitochondria which has been known for some time. It is also an early response, proceeding on a timescale of hours instead of days."

The deterioration of mechanisms designed to maintain the integrity and function of mitochondria throughout the lifetime of a cell has been suggested to underlie the progression of several neurodegenerative diseases, including Parkinson's disease. When mitochondria, the "power plants" of the cell that provide energy, malfunction they can contribute to Parkinson's disease. If they are to survive and function mitochondria need to degrade oxidized and damaged proteins.

In the study, immunofluorescence and confocal microscopy were used to observe how the vesicles "pinch off" from mitochondria with their damaged cargo. "Our conclusion is that the loss of this PINK1 and parkin-dependent trafficking system impairs the ability of mitochondria to selectively degrade oxidized and damaged proteins and leads, over time, to the mitochondrial dysfunction noted in hereditary Parkinson's disease," said Heidi McBride, Professor in the Neuromuscular Group in the Department of Neurology and Neurosurgery at the Montreal Neurological Institute and Hospital.

Both salvage pathways are operational in the cell. If the vesicular pathway, the first line of defense, is overwhelmed and the damage is irreversible then the entire organelle is targeted for degradation.


Story Source:

The above story is based on materials provided by EMBO - excellence in life sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gian-Luca McLelland, Vincent Soubannier, Carol X Chen, Heidi M McBride, Edward A Fon. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. The EMBO Journal, 2014; DOI: 10.1002/embj.201385902

Cite This Page:

EMBO - excellence in life sciences. "Quality control of mitochondria as defense against disease." ScienceDaily. ScienceDaily, 20 January 2014. <www.sciencedaily.com/releases/2014/01/140120090420.htm>.
EMBO - excellence in life sciences. (2014, January 20). Quality control of mitochondria as defense against disease. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/01/140120090420.htm
EMBO - excellence in life sciences. "Quality control of mitochondria as defense against disease." ScienceDaily. www.sciencedaily.com/releases/2014/01/140120090420.htm (accessed November 28, 2014).

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