Featured Research

from universities, journals, and other organizations

Successful regeneration of human skeletal muscle in mice

Date:
January 27, 2014
Source:
Kennedy Krieger Institute
Summary:
Researchers recently announced study findings showing the successful development of a humanized preclinical model for facioscapulohumeral muscular dystrophy, providing scientists with a much needed tool to accelerate novel therapeutic research and development.

Researchers at the Kennedy Krieger Institute recently announced study findings showing the successful development of a humanized preclinical model for facioscapulohumeral muscular dystrophy (FSHD), providing scientists with a much needed tool to accelerate novel therapeutic research and development.

Published in Human Molecular Genetics, the study outlines the validity of a unique model that, for the first time, mirrors the gene expression and biomarker profile of human FSHD tissue. Previously, there has been no accepted preclinical model for FSHD, a complex and rare neuromuscular disorder that affects approximately 4-7 per 100,000 individuals. As a result, therapeutic development for the disorder has been stymied.

"The inability to mimic the FSHD's genetic mechanism in preclinical models has been an ongoing challenge for the research community. Without an accurate model, making the leap to clinical research commonly fails," said Kathryn Wagner MD, PhD, director of the Center for Genetic Muscle Disorders at the Kennedy Krieger Institute in Baltimore, MD. "We believe this unique model will open the door to studying muscle regeneration over time and help better predict clinical response to therapeutic drugs."

Inspired by cancer preclinical models developed with human tumor tissue, Dr. Wagner and her research team leveraged both basic science and clinical research resources available at Kennedy Krieger to successfully regenerate grafted muscle within the models. Human bicep muscle biopsies transplanted into models survived for over 41 weeks and retained features of normal and diseased tissue.

"This model is not only applicable to genetic muscle diseases for which we lack appropriate research models, but for other acquired muscle conditions," said Wagner. "Now there will be more research possibilities related to the overall impact of age and disease on the regenerative and growth capacity of human skeletal muscle."


Story Source:

The above story is based on materials provided by Kennedy Krieger Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Zhang, O. D. King, F. Rahimov, T. I. Jones, C. W. Ward, J. P. Kerr, N. Liu, C. P. Emerson, L. M. Kunkel, T. A. Partridge, K. R. Wagner. Human skeletal muscle xenograft as a new preclinical model for muscle disorders. Human Molecular Genetics, 2014; DOI: 10.1093/hmg/ddu028

Cite This Page:

Kennedy Krieger Institute. "Successful regeneration of human skeletal muscle in mice." ScienceDaily. ScienceDaily, 27 January 2014. <www.sciencedaily.com/releases/2014/01/140127141800.htm>.
Kennedy Krieger Institute. (2014, January 27). Successful regeneration of human skeletal muscle in mice. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/01/140127141800.htm
Kennedy Krieger Institute. "Successful regeneration of human skeletal muscle in mice." ScienceDaily. www.sciencedaily.com/releases/2014/01/140127141800.htm (accessed October 20, 2014).

Share This



More Plants & Animals News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

AP (Oct. 17, 2014) Two white lion cubs were born in Belgrade zoo three weeks ago. White lions are a rare mutation of a species found in South Africa and some cultures consider them divine. (Oct. 17) Video provided by AP
Powered by NewsLook.com
The Best Foods To Boost Your Mood

The Best Foods To Boost Your Mood

Buzz60 (Oct. 17, 2014) Feeling down? Reach for the refrigerator, not the medicine cabinet! TC Newman (@PurpleTCNewman) shares some of the best foods to boost your mood. Video provided by Buzz60
Powered by NewsLook.com
Sweet Times for Hard Cider Makers

Sweet Times for Hard Cider Makers

AP (Oct. 16, 2014) With hard cider making a hardcore comeback across the country, craft makers are trying to keep up with demand and apple growers are tapping a juicy new revenue stream. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Meet Garfi the Angry Cat

Meet Garfi the Angry Cat

Buzz60 (Oct. 16, 2014) Garfi is one frowny, feisty feline - downright angry! Ko Im (@koimtv) introduces us to the latest animal celebrity taking over the Internet. You can follow more of Garfi's adventures on Twitter (@MeetGarfi) and Facebook (Garfi). Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins