Featured Research

from universities, journals, and other organizations

Finding a target for tumor suppression: Protein discovered that blocks scaffolding during cell division

Date:
February 3, 2014
Source:
Brigham Young University
Summary:
Biochemists found a protein that is suspected as a potential tumor suppressor and found how it could block the production of the material used as scaffolding during cell division.

Willardson with Ph.D student Chris Tracy, a co-author on the study.
Credit: Brigham Young University

One of the hopes for victory against cancer hinges on naturally-occurring proteins whose job is to make their host cell die.

Related Articles


Since their natural role is to stop unhealthy cell proliferation, the idea is that one or more of these proteins could be harnessed to stop the growth of tumors.

Brigham Young University scientists recently stumbled onto one potential tumor suppressor with an especially ominous name: Programmed Cell Death Protein 5 (aka PDCD5). What they found opens a new avenue for cancer researchers; in fact, the Journal of Biological Chemistry recognizes the work as their research paper of the week.

Programmed cell death and serendipity

It's tricky to find how and where potential tumor-suppressing proteins do their work inside live cells. Although other labs actively hunted for PDCD5's cellular workplace, the researchers who actually found it weren't looking for it at all.

BYU chemist Barry Willardson and his team study totally different proteins called molecular chaperones, which help other proteins to fold into their proper shape.

But proteins are like teenagers in a sense: You can learn a lot by noticing who they hang out with. So the Willardson group went in search of the chaperone's buddies.

"It's a great type of experiment because it tells you things that you may not have considered," Willardson said.

So when they spotted PDCD5 hooking up with their protein, they wondered if its tumor suppressor ability was linked to the chaperone.

To get a closer look at the pairing, the BYU team collaborated with scientists in Madrid who operate a cryo-electron microscope in Spain's National Center of Biotechnology. Their images showed how the mysterious Programmed Cell Death Protein 5 could block the production of tubulin, the material that cells use as scaffolding during cell division.

What this means for cancer research

Hundreds of proteins have been targeted for their potential to suppress tumors. This study identifies how one of those proteins may keep the growth of healthy cells in check.

"We've provided information on how this protein functions, and it needs to remain functional to be a tumor suppressor," Willardson said. "It really is just a first step, but it gives us a direction we want to follow."


Story Source:

The above story is based on materials provided by Brigham Young University. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. M. Tracy, A. J. Gray, J. Cuellar, T. S. Shaw, A. C. Howlett, R. M. Taylor, J. T. Prince, N. G. Ahn, J. M. Valpuesta, B. M. Willardson. Programmed Cell Death Protein 5 Interacts with the Cytosolic Chaperonin CCT to Regulate -tubulin Folding. Journal of Biological Chemistry, 2013; DOI: 10.1074/jbc.M113.542159

Cite This Page:

Brigham Young University. "Finding a target for tumor suppression: Protein discovered that blocks scaffolding during cell division." ScienceDaily. ScienceDaily, 3 February 2014. <www.sciencedaily.com/releases/2014/02/140203191833.htm>.
Brigham Young University. (2014, February 3). Finding a target for tumor suppression: Protein discovered that blocks scaffolding during cell division. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2014/02/140203191833.htm
Brigham Young University. "Finding a target for tumor suppression: Protein discovered that blocks scaffolding during cell division." ScienceDaily. www.sciencedaily.com/releases/2014/02/140203191833.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Newsy (Apr. 20, 2015) Five years on, the possible environmental impact of the Deepwater Horizon spill includes a sustained die-off of bottlenose dolphins, among others. Video provided by Newsy
Powered by NewsLook.com
Five Years Later, the BP Oil Spill Is Still Taking Its Toll

Five Years Later, the BP Oil Spill Is Still Taking Its Toll

AFP (Apr. 20, 2015) On April 20, 2010, an explosion and fire on the Deepwater Horizon rig in the Gulf of Mexico started the biggest oil spill in US history. BP recently reported the Gulf is recovering well, but scientists paint a different picture. Duration: 02:36 Video provided by AFP
Powered by NewsLook.com
Thai Customs Seize African Elephant Tusks Worth $6 Mn

Thai Customs Seize African Elephant Tusks Worth $6 Mn

AFP (Apr. 20, 2015) Thai customs seize four tonnes of African elephant ivory worth $6 million at a Bangkok port in a container labelled as beans. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins