Featured Research

from universities, journals, and other organizations

Machinery responsible for the entry of proteins into cell membranes unravelled, solving long mystery

Date:
February 18, 2014
Source:
University of Bristol
Summary:
The nature of the machinery responsible for the entry of proteins into cell membranes has been unravelled by scientists, who hope the breakthrough could ultimately be exploited for the design of new anti-bacterial drugs. Groups of researchers used new genetic engineering technologies to reconstruct and isolate the cell's protein trafficking machinery. Its analysis has shed new light on a process which had previously been a mystery for molecular biologists.

Researchers were able to identify the ‘holo-translocon’ as the machinery which inserts proteins into the membrane. It is a large membrane protein complex and is uniquely capable of both protein-secretion and membrane-insertion.
Credit: Image courtesy of University of Bristol

The nature of the machinery responsible for the entry of proteins into cell membranes has been unravelled by scientists, who hope the breakthrough could ultimately be exploited for the design of new anti-bacterial drugs. Groups of researchers from the University of Bristol and the European Molecular Biology Laboratory (EMBL) used new genetic engineering technologies to reconstruct and isolate the cell's protein trafficking machinery.

Related Articles


Its analysis has shed new light on a process which had previously been a mystery for molecular biologists.

The findings, published in the Proceedings of the National Academy of Sciences (PNAS), could also have applications for synthetic biology -- an emerging field of science and technology, for the development of novel membrane proteins with useful activities.

Proteins are the building blocks of all life and are essential for the growth of cells and tissue repair. The proteins in the membrane typically help the cell interact with its environment and conserve energy.

Researchers were able to identify the 'holo-translocon' as the machinery which inserts proteins into the membrane. It is a large membrane protein complex and is uniquely capable of both protein-secretion and membrane-insertion.

Professor Ian Collinson, from the School of Biochemistry at Bristol University said: "These findings are important as they address outstanding questions in one of the central pillars of biology, a process essential in every cell in every organism. Having unravelled how this vital holo-translocon works, we're now in a position to look at its components to see if they can help in the design or screening for new anti-bacterial drugs."

The discovery is a result of an international collaboration between the University of Bristol team and Drs Christiane Schaffitzel and Imre Berger of the European Molecular Biology Laboratory (EMBL) outstation in Grenoble, France.


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. J. Schulze, J. Komar, M. Botte, W. J. Allen, S. Whitehouse, V. A. M. Gold, J. A. Lycklama a Nijeholt, K. Huard, I. Berger, C. Schaffitzel, I. Collinson. Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG-SecDF-YajC-YidC. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1315901111

Cite This Page:

University of Bristol. "Machinery responsible for the entry of proteins into cell membranes unravelled, solving long mystery." ScienceDaily. ScienceDaily, 18 February 2014. <www.sciencedaily.com/releases/2014/02/140218124542.htm>.
University of Bristol. (2014, February 18). Machinery responsible for the entry of proteins into cell membranes unravelled, solving long mystery. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2014/02/140218124542.htm
University of Bristol. "Machinery responsible for the entry of proteins into cell membranes unravelled, solving long mystery." ScienceDaily. www.sciencedaily.com/releases/2014/02/140218124542.htm (accessed October 30, 2014).

Share This



More Plants & Animals News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How A Chorus Led Scientists To A New Frog Species

How A Chorus Led Scientists To A New Frog Species

Newsy (Oct. 30, 2014) A frog noticed by a conservationist on New York's Staten Island has been confirmed as a new species after extensive study and genetic testing. Video provided by Newsy
Powered by NewsLook.com
Surfer Accidentally Stands on Shark, Gets Bitten

Surfer Accidentally Stands on Shark, Gets Bitten

AP (Oct. 30, 2014) A 20-year-old competition surfer said on Thursday he accidentally stepped on a shark's head before it bit him off the Australian east coast. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Ebola Inflicts Heavy Toll on Guinean Potato Trade

Ebola Inflicts Heavy Toll on Guinean Potato Trade

AFP (Oct. 30, 2014) The Ebola epidemic has seen Senegal and Guinea Bissau close its borders with Guinea and the economic consequences have started to be felt, especially in Fouta Djallon, where the renowned potato industry has been hit hard. Duration: 02:01 Video provided by AFP
Powered by NewsLook.com
Genetically Altered Glowing Flower on Display in Tokyo

Genetically Altered Glowing Flower on Display in Tokyo

Reuters - Innovations Video Online (Oct. 30, 2014) Just in time for Halloween, a glowing flower goes on display in Tokyo. Instead of sorcery and magic, its creators used science to genetically modify the flower, adding a naturally fluorescent plankton protein to its genetic mix. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins