Featured Research

from universities, journals, and other organizations

Researchers identify 'carbohydrates in a coal mine' for cancer detection

Date:
March 3, 2014
Source:
New York University
Summary:
Carbohydrates serve as identifiers for cancer cells, researchers have discovered. Their findings show how these molecules may serve as signals for cancer and explain what’s going on inside these cells, pointing to new ways in which sugars function as a looking glass into the workings of their underlying structures. "Carbohydrates can tell us a lot about what's going on inside of a cell, so they are potentially good markers for disease," the lead author notes.

Researchers at New York University and the University of Texas at Austin have discovered that carbohydrates serve as identifiers for cancer cells. Their findings, which appear in the journal Proceedings of the National Academy of Sciences, show how these molecules may serve as signals for cancer and explain what's going on inside these cells, pointing to new ways in which sugars function as a looking glass into the workings of their underlying structures.

Related Articles


"Carbohydrates can tell us a lot about what's going on inside of a cell, so they are potentially good markers for disease," said Lara Mahal, an associate professor in NYU's Department of Chemistry and the study's corresponding author. "Our study reveals how cancer cells produce certain 'carbohydrate signatures' that we can now identify."

Carbohydrates, or glycans, are complex cell-surface molecules that control multiple aspects of cell biology, including cancer metastasis. But less understood is the link between categories of cells and corresponding carbohydrate structures. That is, what do certain carbohydrates on a cell's surfaces tell us about its characteristics and inner workings or, more succinctly, how do you read a code backwards?

In the PNAS study, the researchers examined the role of microRNA, non-coding RNA that are regulators of the genome. Specific miRNAs -- such as miR-200 -- play a role in controlling tumor growth. Using microarray technology developed by NYU's Mahal, the team examined cancer cells in an effort to see how they generated a carbohydrate signature. Specifically, they mapped how miRNA controls carbohydrate signatures.

In their analysis, the researchers could see that miRNA molecules serve as major regulators of the cell's surface-level carbohydrates -- a discovery that showed, for the first time, that miRNA play a significant regulatory role in this part of the cell, also known as the glycome. Moreover, they could see which regulatory process was linked to specific carbohydrates.

"Carbohydrates aren't just telling you the type of cell they came from, but also by which process they were created," explains Mahal. "Our results showed that there are regulatory networks of miRNAs and that they are associated with specific carbohydrate codes."


Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Agrawal, T. Kurcon, K. T. Pilobello, J. F. Rakus, S. Koppolu, Z. Liu, B. S. Batista, W. S. Eng, K.-L. Hsu, Y. Liang, L. K. Mahal. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1321524111

Cite This Page:

New York University. "Researchers identify 'carbohydrates in a coal mine' for cancer detection." ScienceDaily. ScienceDaily, 3 March 2014. <www.sciencedaily.com/releases/2014/03/140303153930.htm>.
New York University. (2014, March 3). Researchers identify 'carbohydrates in a coal mine' for cancer detection. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2014/03/140303153930.htm
New York University. "Researchers identify 'carbohydrates in a coal mine' for cancer detection." ScienceDaily. www.sciencedaily.com/releases/2014/03/140303153930.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins