Featured Research

from universities, journals, and other organizations

Genetic differences in female athletes with ACL injuries found in study

Date:
March 13, 2014
Source:
American Academy of Orthopaedic Surgeons
Summary:
For the first time, a new study identified varied female-to-male expression of ribonucleic acid molecules leading to proteins maintaining ligament structure, that could explain why females are more likely to suffer an anterior cruciate ligament injury than males.

Female athletes are two-to-eight times more likely to suffer an anterior cruciate ligament (ACL) injury than males. And while there has been speculation on possible anatomic, hormonal and neuromuscular factors that may place females at greater risk for these injuries, little research has looked specifically at the role of genetics.

For the first time, a new study identified varied female-to-male expression of ribonucleic acid (RNA) molecules leading to proteins maintaining ligament structure.

In the study, "Gene Expression Differences in Young Male and Female Ruptured Anterior Cruciate Ligaments," a biopsy of normally discarded ruptured ACL tissue was obtained during surgery from seven male and seven female young athlete patients. Biopsies were then divided into groups for microscopic (histological) and genetic analysis. Thirty-two significantly differentially expressed genes were isolated from male and female tissue, of which 14 were neither linked to the X or Y chromosome.

The 14 remaining genes were then grouped according to skeletal muscular development, function and cellular growth. In females, compared to males, the microarray analysis showed altered responses in signaling pathways that regulate cartilage and tissue growth.

The study authors believe the findings represent "the tip of the iceberg" in terms of determining the role of genetics in ACL structure and tendency toward increased ligament injury in female compared to male athletes.

Abstract to the presentation on this research can be found at: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=3358&sKey=47b6cfe1-82d8-4509-9b33-7f7473c13f0d&cKey=22499357-aa6a-42e8-9107-ba8e78b71386&mKey=4393d428-d755-4a34-8a63-26b1b7a349a1


Story Source:

The above story is based on materials provided by American Academy of Orthopaedic Surgeons. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Orthopaedic Surgeons. "Genetic differences in female athletes with ACL injuries found in study." ScienceDaily. ScienceDaily, 13 March 2014. <www.sciencedaily.com/releases/2014/03/140313092609.htm>.
American Academy of Orthopaedic Surgeons. (2014, March 13). Genetic differences in female athletes with ACL injuries found in study. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/03/140313092609.htm
American Academy of Orthopaedic Surgeons. "Genetic differences in female athletes with ACL injuries found in study." ScienceDaily. www.sciencedaily.com/releases/2014/03/140313092609.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins