Featured Research

from universities, journals, and other organizations

Genetic differences in female athletes with ACL injuries found in study

Date:
March 13, 2014
Source:
American Academy of Orthopaedic Surgeons
Summary:
For the first time, a new study identified varied female-to-male expression of ribonucleic acid molecules leading to proteins maintaining ligament structure, that could explain why females are more likely to suffer an anterior cruciate ligament injury than males.

Female athletes are two-to-eight times more likely to suffer an anterior cruciate ligament (ACL) injury than males. And while there has been speculation on possible anatomic, hormonal and neuromuscular factors that may place females at greater risk for these injuries, little research has looked specifically at the role of genetics.

Related Articles


For the first time, a new study identified varied female-to-male expression of ribonucleic acid (RNA) molecules leading to proteins maintaining ligament structure.

In the study, "Gene Expression Differences in Young Male and Female Ruptured Anterior Cruciate Ligaments," a biopsy of normally discarded ruptured ACL tissue was obtained during surgery from seven male and seven female young athlete patients. Biopsies were then divided into groups for microscopic (histological) and genetic analysis. Thirty-two significantly differentially expressed genes were isolated from male and female tissue, of which 14 were neither linked to the X or Y chromosome.

The 14 remaining genes were then grouped according to skeletal muscular development, function and cellular growth. In females, compared to males, the microarray analysis showed altered responses in signaling pathways that regulate cartilage and tissue growth.

The study authors believe the findings represent "the tip of the iceberg" in terms of determining the role of genetics in ACL structure and tendency toward increased ligament injury in female compared to male athletes.

Abstract to the presentation on this research can be found at: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=3358&sKey=47b6cfe1-82d8-4509-9b33-7f7473c13f0d&cKey=22499357-aa6a-42e8-9107-ba8e78b71386&mKey=4393d428-d755-4a34-8a63-26b1b7a349a1


Story Source:

The above story is based on materials provided by American Academy of Orthopaedic Surgeons. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Orthopaedic Surgeons. "Genetic differences in female athletes with ACL injuries found in study." ScienceDaily. ScienceDaily, 13 March 2014. <www.sciencedaily.com/releases/2014/03/140313092609.htm>.
American Academy of Orthopaedic Surgeons. (2014, March 13). Genetic differences in female athletes with ACL injuries found in study. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2014/03/140313092609.htm
American Academy of Orthopaedic Surgeons. "Genetic differences in female athletes with ACL injuries found in study." ScienceDaily. www.sciencedaily.com/releases/2014/03/140313092609.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins