Featured Research

from universities, journals, and other organizations

Genetic differences in female athletes with ACL injuries found in study

Date:
March 13, 2014
Source:
American Academy of Orthopaedic Surgeons
Summary:
For the first time, a new study identified varied female-to-male expression of ribonucleic acid molecules leading to proteins maintaining ligament structure, that could explain why females are more likely to suffer an anterior cruciate ligament injury than males.

Female athletes are two-to-eight times more likely to suffer an anterior cruciate ligament (ACL) injury than males. And while there has been speculation on possible anatomic, hormonal and neuromuscular factors that may place females at greater risk for these injuries, little research has looked specifically at the role of genetics.

Related Articles


For the first time, a new study identified varied female-to-male expression of ribonucleic acid (RNA) molecules leading to proteins maintaining ligament structure.

In the study, "Gene Expression Differences in Young Male and Female Ruptured Anterior Cruciate Ligaments," a biopsy of normally discarded ruptured ACL tissue was obtained during surgery from seven male and seven female young athlete patients. Biopsies were then divided into groups for microscopic (histological) and genetic analysis. Thirty-two significantly differentially expressed genes were isolated from male and female tissue, of which 14 were neither linked to the X or Y chromosome.

The 14 remaining genes were then grouped according to skeletal muscular development, function and cellular growth. In females, compared to males, the microarray analysis showed altered responses in signaling pathways that regulate cartilage and tissue growth.

The study authors believe the findings represent "the tip of the iceberg" in terms of determining the role of genetics in ACL structure and tendency toward increased ligament injury in female compared to male athletes.

Abstract to the presentation on this research can be found at: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=3358&sKey=47b6cfe1-82d8-4509-9b33-7f7473c13f0d&cKey=22499357-aa6a-42e8-9107-ba8e78b71386&mKey=4393d428-d755-4a34-8a63-26b1b7a349a1


Story Source:

The above story is based on materials provided by American Academy of Orthopaedic Surgeons. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Orthopaedic Surgeons. "Genetic differences in female athletes with ACL injuries found in study." ScienceDaily. ScienceDaily, 13 March 2014. <www.sciencedaily.com/releases/2014/03/140313092609.htm>.
American Academy of Orthopaedic Surgeons. (2014, March 13). Genetic differences in female athletes with ACL injuries found in study. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2014/03/140313092609.htm
American Academy of Orthopaedic Surgeons. "Genetic differences in female athletes with ACL injuries found in study." ScienceDaily. www.sciencedaily.com/releases/2014/03/140313092609.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins