Featured Research

from universities, journals, and other organizations

Treatment for deadly yeast disease reduced to three days

Date:
April 24, 2014
Source:
University of Liverpool
Summary:
Initial treatment for a brain infection caused by fungus could now be treated in three days, rather than two weeks, due to new research. Cryptococcus -- a form of yeast -- infections are often fatal but are relatively neglected in medical research. They are found in many parts of the world, including Africa, Australasia and South East Asia and mainly affect people with weakened immune systems. This infection kills up to 700,000 people a year.

Initial treatment for a brain infection caused by fungus could now be treated in three days, rather than two weeks, due to study by University of Liverpool scientists.

Cryptococcus -- a form of yeast -- infections are often fatal but are relatively neglected in medical research. They are found in many parts of the world, including Africa, Australasia and South East Asia and mainly affect people with weakened immune systems. This infection kills up to 700,000 people a year.

The University research team has tested the effects of the most commonly used drug on Cryptococcus infections of the brain and discovered that although the recommendation for treatment is currently two weeks, the drug has been shown by the new studies to be effective at clearing the fungus within three days.

Professor of Therapeutics and Infectious Diseases, William Hope said: "This infection kills up to 700,000 people a year and is mainly fatal in areas with poor resources. In many parts of the world it is simply infeasible to administer intravenous drugs for two weeks."

The scientists in the Institute of Translational Medicine examined the effects of amphotericin B deoxycholate (dAmB) over both three and 14 day treatments and found that the effect was the same after three days as it was after two weeks.

The results in animal trials was compared with humans using a range of mathematical modelling techniques, to produce findings which suggest that the three day regime will be equally as effective in people.

The researchers believe that this opens up significant possibilities for treatment in areas where there is a scarcity of medically trained staff, who often have to ration the drugs they administer to patients.

The infection often takes hold in people with AIDS as a result of their immune systems being compromised, and areas with high rates of AIDS are also usually those without resources.

Professor Hope added: "A lot of the treatment administered with a variety of drugs is assumed and generalised. This is one example of how experimental medicine can help accelerate changes to improve outcomes for patients."

The next stage of the research will be to test it in clinical trials in humans. The findings were published in the journal mBio.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Livermore, S. J. Howard, A. D. Sharp, J. Goodwin, L. Gregson, T. Felton, J. A. Schwartz, C. Walker, B. Moser, W. Muller, T. S. Harrison, J. R. Perfect, W. W. Hope. Efficacy of an Abbreviated Induction Regimen of Amphotericin B Deoxycholate for Cryptococcal Meningoencephalitis: 3 Days of Therapy Is Equivalent to 14 Days. mBio, 2014; 5 (1): e00725-13 DOI: 10.1128/mBio.00725-13

Cite This Page:

University of Liverpool. "Treatment for deadly yeast disease reduced to three days." ScienceDaily. ScienceDaily, 24 April 2014. <www.sciencedaily.com/releases/2014/04/140424102607.htm>.
University of Liverpool. (2014, April 24). Treatment for deadly yeast disease reduced to three days. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2014/04/140424102607.htm
University of Liverpool. "Treatment for deadly yeast disease reduced to three days." ScienceDaily. www.sciencedaily.com/releases/2014/04/140424102607.htm (accessed September 23, 2014).

Share This



More Plants & Animals News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Will Living Glue Be A Thing?

Will Living Glue Be A Thing?

Newsy (Sep. 23, 2014) Using proteins derived from mussels, engineers at MIT have made a supersticky underwater adhesive. They're now looking to make "living glue." Video provided by Newsy
Powered by NewsLook.com
Raw: Tiger Kills Man at India Zoo

Raw: Tiger Kills Man at India Zoo

AP (Sep. 23, 2014) A white tiger killed a young man who climbed over a fence at the New Delhi zoo and jumped into the animal's enclosure on Tuesday, a spokesman said. (Sept. 23) Video provided by AP
Powered by NewsLook.com
Cat Lovers Flock to Los Angeles

Cat Lovers Flock to Los Angeles

AFP (Sep. 22, 2014) The best funny internet cat videos are honoured at LA's Feline Film Festival. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
Washed-Up 'Alien Hairballs' Are Actually Algae

Washed-Up 'Alien Hairballs' Are Actually Algae

Newsy (Sep. 22, 2014) Green balls of algae washed up on Sydney, Australia's Dee Why Beach. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins