Featured Research

from universities, journals, and other organizations

New sensor molecules have potential for early cancer detection

Date:
April 25, 2014
Source:
Suomen Akatemia (Academy of Finland)
Summary:
A new water-soluble fluorescent detection system that is extremely sensitive to pyrophosphate (PPi) has been discovered by researchers. Pyrophosphate has a key role in energy transduction, DNA replication and other metabolic processes that are dysregulated in cancer cells. The discovery might lead to the development of a method for early detection of cancer cells.

A research team lead by Academy Professor Kari Rissanen at the University of Jyväskylä has discovered a new water-soluble fluorescent detection system that is extremely sensitive to pyrophosphate (PPi).

Related Articles


Pyrophosphate has a key role in energy transduction, DNA replication and other metabolic processes that are dysregulated in cancer cells. The discovery might lead to the development of a method for early detection of cancer cells.

The team developed a simple metal complex which shows an intense orange fluorescent color in the presence of very low concentration of pyrophosphate (PPi) in water. The complex, also called a probe, had almost 1000 times higher level of response than earlier methods and an unprecedented sensitivity to detect PPi at a sub-nanomolar level (LOD ∼ 0.8 nM). The discovery represents the first water-soluble fluorescent sensor that is capable of detecting pyrophosphate at this sensitivity level under physiological conditions.

The highly sensitive probes or sensors that are able to report the PPi level could lead to improved cancer diagnostics, since PPi plays a key role in energy transduction, DNA replication and other metabolic processes that are seriously misbehaving in cancer cells. All earlier PPi-selective sensor molecules or complexes have suffered from poor water solubility and low sensitivity in water. They can reach only micromolar levels and, thus, researchers have had to rely on protein-based probes that have their own limitations.

The researchers were able to show that the probe can image the pyrophosphate in the nuclei of living (HeLa) cells, making it an excellent probe for live cell pyrophosphahe imaging. The HeLa cells, originally from Henrietta Lack's cervix carcinoma, are the most long-lived human cancer cell line and are often used as a cancer cell model. In addition to their applicability in water, they can easily be formulated into a hydrogel and coated onto paper strips for low-cost pyrophosphate detection.


Story Source:

The above story is based on materials provided by Suomen Akatemia (Academy of Finland). Note: Materials may be edited for content and length.


Journal Reference:

  1. ACS Contributing Correspondents. Spotlights on RecentJACSPublications. Journal of the American Chemical Society, 2014; 136 (15): 5525 DOI: 10.1021/ja5035039

Cite This Page:

Suomen Akatemia (Academy of Finland). "New sensor molecules have potential for early cancer detection." ScienceDaily. ScienceDaily, 25 April 2014. <www.sciencedaily.com/releases/2014/04/140425075017.htm>.
Suomen Akatemia (Academy of Finland). (2014, April 25). New sensor molecules have potential for early cancer detection. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2014/04/140425075017.htm
Suomen Akatemia (Academy of Finland). "New sensor molecules have potential for early cancer detection." ScienceDaily. www.sciencedaily.com/releases/2014/04/140425075017.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) — The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) — President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) — Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) — The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins