Featured Research

from universities, journals, and other organizations

New method to analyze how cancer cells die

Date:
April 28, 2014
Source:
Manchester University
Summary:
The number of cells within tissue is controlled through apoptosis -- a process where cells shrink and their components break up, also known as programmed cell death. Cancer is often characterized by a disruption to the normal process of this cell death. Being able to study this process accurately would allow doctors to more effectively diagnose and monitor cancer and to test and develop new treatments designed to kill cancer cells. Thanks to new research, scientists are a step closer to this.

Manchester scientists have improved a way of analyzing how cancer spreads and how effective drugs are at killing the cells.

Related Articles


A team from The University of Manchester -- part of the Manchester Cancer Research Centre -- have found a new method to more efficiently manufacture a chemical used to monitor cancer cells.

The technique could lead to clearer and better quality images on PET scans. The number of cells within tissue is controlled through apoptosis -- a process where cells shrink and their components break up, also known as programmed cell death. Cancer is often characterised by a disruption to the normal process of this cell death.

Being able to study this process accurately would allow doctors to more effectively diagnose and monitor cancer and to test and develop new treatments designed to kill cancer cells. Ideally, cell death would be measured non-invasively to avoid surgery and current methods are focused on using radioactive tracers -- molecules that are taken up in regions of tissue where cells are breaking apart as they die.

These tracers release radiation that can be detected using a scanner. The resulting scan images show where the tracer is concentrated and therefore where cell death activity is highest. One such tracer -- ML-10 -- accumulates where there are dying cells.

By labelling this molecule with radioactive fluorine -- that results in gamma rays that can be detected by scanners -- and injecting it into patients, scientists can detect where cell death is taking place using a PET scan. Manchester researchers have developed a new manufacturing process for ML-10, and tested the tracer in mice, and have also shown how to make an alternative, potentially better, tracer with a similar chemical structure.

Dr Gavin Brown, who led the research, said: "Measurement of cell death could help doctors monitor new anticancer therapies. We have devised a new way to manufacture this tracer, and an alternate form, that could potentially improve the quality of PET images." The team reported their results recently in the journal Bioorganic and Medicinal Chemistry.

Their method involves several stages of carefully reacting chemicals together in order to achieve the required product. They found that their new method was better at making the tracer stick to dying cells -- this will allow medics to monitor what is happening and makes it easer to detect the dying cells. In addition, they showed that the alternate form of ML-10 could also be used to detect cell death.

"This new chemical will lead to clearer and better quality images. The preliminary results we have achieved are very promising and we feel that our new approach warrants further investigation," added Dr Brown.


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Manikandan Kadirvel, Michael Fairclough, Christopher Cawthorne, Emily J. Rowling, Muhammad Babur, Adam McMahon, Paul Birkket, Alison Smigova, Sally Freeman, Kaye J. Williams, Gavin Brown. Detection of apoptosis by PET/CT with the diethyl ester of [18F]ML-10 and fluorescence imaging with a dansyl analogue. Bioorganic & Medicinal Chemistry, 2014; 22 (1): 341 DOI: 10.1016/j.bmc.2013.11.019

Cite This Page:

Manchester University. "New method to analyze how cancer cells die." ScienceDaily. ScienceDaily, 28 April 2014. <www.sciencedaily.com/releases/2014/04/140428120803.htm>.
Manchester University. (2014, April 28). New method to analyze how cancer cells die. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/04/140428120803.htm
Manchester University. "New method to analyze how cancer cells die." ScienceDaily. www.sciencedaily.com/releases/2014/04/140428120803.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins