Featured Research

from universities, journals, and other organizations

DNA repair gene provides new ideas for disease treatment

Date:
April 30, 2014
Source:
Landes Bioscience
Summary:
A gene known to repair DNA damage in healthy cells may also provide new insights about treating a genetic disorder of the bone marrow, researchers say. "Since much is known about the mechanism of action of DNA2, it is an attractive target for future drug treatments -- like small-molecule inhibitors that could reduce an FA patient's cancer predisposition -- as well as a possible gene therapy for aiding a patient's blood cell development," says the study's leader.

A gene known to repair DNA damage in healthy cells may also provide new insights about treating a genetic disorder of the bone marrow, Caltech researchers say.

This finding was published in the May 15 print edition of the journal Cell Cycle.

In the study led by Judith Campbell, professor of chemistry and biology at Caltech, the researchers investigated the relationship between two genes -- FANCD2 and DNA2 -- both known to play roles in fixing broken or damaged strands of DNA within a cell, called DNA repair. A defective version of the FANCD2 gene can result in the genetic disease Fanconi anemia (FA), which is characterized by failure of the bone marrow (an inability to replenish the body's supply of blood cells) and a predisposition to certain developmental disorders and cancers. Although DNA2 has not been associated with an FA family as yet, genetic studies implicate DNA2 in the FA DNA repair pathway.

To determine the relationship between the genes, the researchers applied formaldehyde and other DNA-damaging substances to three types of cells: those lacking FANCD2, those lacking DNA2, and cells lacking both FANCD2 and DNA2. The groups of cells in which only one of the two genes had been deleted quickly succumbed to the formaldehyde-induced DNA damage; however, the cells lacking both FANCD2 and DNA2 were able to repair the DNA damage and survive.

"A key implication of this finding is the potential to manipulate DNA2 to improve the survival of FANCD2-deficient cells, and hopefully, by extension, the survival of FA patients," says Kenneth Karanja, a former postdoctoral scholar in Campbell's laboratory and first author on the study. Currently, the only treatment for FA is a bone marrow transplant, but even after the transplant the disease remains lethal.

"DNA2 is a well-studied gene, and this recent discovery could potentially become the basis for ameliorating the symptoms of this incurable disorder," Campbell says. Furthermore, she says, the protein DNA2 encodes is a nuclease -- which is a specific type of enzyme that has become a promising drug target.

"Since much is known about the mechanism of action of DNA2, it is an attractive target for future drug treatments -- like small-molecule inhibitors that could reduce an FA patient's cancer predisposition -- as well as a possible gene therapy for aiding a patient's blood cell development," she says.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kenneth K Karanja, Eu Han Lee, Eric A Hendrickson, Judith L Campbell. Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells. Cell Cycle, 2014; 13 (10): 0 DOI: 10.4161/cc.28476

Cite This Page:

Landes Bioscience. "DNA repair gene provides new ideas for disease treatment." ScienceDaily. ScienceDaily, 30 April 2014. <www.sciencedaily.com/releases/2014/04/140430121122.htm>.
Landes Bioscience. (2014, April 30). DNA repair gene provides new ideas for disease treatment. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/04/140430121122.htm
Landes Bioscience. "DNA repair gene provides new ideas for disease treatment." ScienceDaily. www.sciencedaily.com/releases/2014/04/140430121122.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins