Featured Research

from universities, journals, and other organizations

New functional roles on cell surfaces for estrogen discovered

Date:
May 27, 2014
Source:
University of California - Irvine
Summary:
The importance of cell surface receptors for estrogen has the potential to change how researchers view the hormone's role in normal organ development and function, a discovery by endocrinologists indicates. The implications of this discovery move beyond development, and can include estrogen's role in causing cancers, or preventing cardiovascular diseases and bone diseases. Current therapeutic efforts propose to target estrogen's ability in the nucleus to turn genes on and off, but researchers note new approaches should also explore irregularities of functions at cell membrane receptors that affect disease.

A discovery by UC Irvine endocrinologists about the importance of cell surface receptors for estrogen has the potential to change how researchers view the hormone's role in normal organ development and function.

Related Articles


To date, scientists in the field focused on receptors in the cell's nucleus as the primary site for estrogen's effect on gene activity and organ development and function. There has been acknowledgement of similar estrogen receptors outside of the nucleus but much debate as to whether they are important.

To investigate this, Dr. Ellis Levin, professor of medicine at UC Irvine, employed a knock-in mouse that prevented the main estrogen receptor, ER-alpha, from trafficking to the cell membrane.

As a result, Levin found that many organs in the female mice were extremely abnormal, including the mammary gland, uterus, and ovaries. Additionally, pituitary hormone production and fat development were also severely impacted, and the mice were completely infertile.

"Until now, research has taken a narrow view on the importance of estrogen signaling outside the nucleus during development," Levin said. "What this study shows is that both nuclear and cell membrane estrogen receptors are required to collaborate for normal organ development and function."

The implications of this discovery move beyond development, Levin added, and can include estrogen's role in causing cancers, or preventing cardiovascular diseases and bone diseases. Current therapeutic efforts propose to target estrogen's ability in the nucleus to turn genes on and off, but Levin notes new approaches should also explore irregularities of functions at cell membrane receptors that affect disease.

"The cell membrane receptor is very sophisticated, impacting the nuclear receptor action and modifying certain proteins and their functions throughout the cells of many organs," Levin said. "By studying how to regulate the partnership between these two receptor sets, and modulate membrane receptor signaling, we can understand how to better treat estrogen-linked diseases and gain benefits in other aspects."


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ali Pedram, Mahnaz Razandi, Michael Lewis, Stephen Hammes, EllisR. Levin. Membrane-Localized Estrogen Receptor α Is Required for Normal Organ Development and Function. Developmental Cell, 2014; 29 (4): 482 DOI: 10.1016/j.devcel.2014.04.016

Cite This Page:

University of California - Irvine. "New functional roles on cell surfaces for estrogen discovered." ScienceDaily. ScienceDaily, 27 May 2014. <www.sciencedaily.com/releases/2014/05/140527124142.htm>.
University of California - Irvine. (2014, May 27). New functional roles on cell surfaces for estrogen discovered. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2014/05/140527124142.htm
University of California - Irvine. "New functional roles on cell surfaces for estrogen discovered." ScienceDaily. www.sciencedaily.com/releases/2014/05/140527124142.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Baby Okapi Born at Houston Zoo

Raw: Baby Okapi Born at Houston Zoo

AP (Nov. 20, 2014) The Houston Zoo released video of a male baby okapi. Okapis, also known as the "forest giraffe", are native to the Democratic Republic of the Congo in Central Africa. Video is mute from source. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins