Featured Research

from universities, journals, and other organizations

Doing more means changing less when it comes to gene response, new study shows

Date:
June 5, 2014
Source:
Suomen Akatemia (Academy of Finland)
Summary:
The more biological functions a gene has, the less it responds to environmental change, a team of researchers has discovered, based on work focused on thermally-adapted fish populations. “In addition to having important implications for climate change adaptation, these findings could radically change the way we study gene responses to any external stimulus like for example to drug treatments,” the authors suggest.

An international team led by scientists at the University of Turku in Finland studied thermally-adapted fish populations to discover that the more biological functions a gene has, the less it responds to environmental change. "In addition to having important implications for climate change adaptation, these findings could radically change the way we study gene responses to any external stimulus like for example to drug treatments," the authors suggest. Their findings are reported on June 3 2014 in the journal Nature Communications.

When organisms need more of a gene's product, typically a protein, the gene is 'turned up' and the opposite occurs when less protein is needed (the gene is 'turned down'). For years, biologists have used this knowledge to identify genes that are important for certain conditions. The logic behind is simple: among genes, those that are 'turned up' or 'turned down' the most will also be the most important. Correct? Not exactly, according to the latest findings.

In their study, Papakostas and co-authors studied the responses to temperature for more than 400 genes in grayling populations (grayling is a relative of Atlantic salmon). "We used state-of-the-art molecular tools that allowed us to measure gene responses directly at the protein level," the authors explain. The breakthrough came when they examined how much each the gene was 'turned up' or 'turned down' in comparison to how many biological functions each gene is known to have. "We found a very clear correlation between how much protein amounts changed in response to temperature and the number gene biological functions. The more the gene biological functions, the less was the protein expression change," S. Papakostas, the primary author of the study explains.

How do these findings change our current view about gene responses? "When it comes to gene expression responses, there is no one simple universal solution and our study shows exactly that. Gene expression changes could not be judged solely based on the magnitude of change because genes with more biological functions simply cannot change as much as genes with fewer biological functions. We need to develop ways that take this into account. We believe the present study represents the first step forward to a whole new direction for molecular and evolutionary biologists," the authors conclude.


Story Source:

The above story is based on materials provided by Suomen Akatemia (Academy of Finland). Note: Materials may be edited for content and length.


Journal Reference:

  1. Spiros Papakostas, L. Asbjψrn Vψllestad, Matthieu Bruneaux, Tutku Aykanat, Joost Vanoverbeke, Mei Ning, Craig R. Primmer, Erica H. Leder. Gene pleiotropy constrains gene expression changes in fish adapted to different thermal conditions. Nature Communications, 2014; 5 DOI: 10.1038/ncomms5071

Cite This Page:

Suomen Akatemia (Academy of Finland). "Doing more means changing less when it comes to gene response, new study shows." ScienceDaily. ScienceDaily, 5 June 2014. <www.sciencedaily.com/releases/2014/06/140605082954.htm>.
Suomen Akatemia (Academy of Finland). (2014, June 5). Doing more means changing less when it comes to gene response, new study shows. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2014/06/140605082954.htm
Suomen Akatemia (Academy of Finland). "Doing more means changing less when it comes to gene response, new study shows." ScienceDaily. www.sciencedaily.com/releases/2014/06/140605082954.htm (accessed September 22, 2014).

Share This



More Plants & Animals News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cat Lovers Flock to Los Angeles

Cat Lovers Flock to Los Angeles

AFP (Sep. 22, 2014) — The best funny internet cat videos are honoured at LA's Feline Film Festival. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
Washed-Up 'Alien Hairballs' Are Actually Algae

Washed-Up 'Alien Hairballs' Are Actually Algae

Newsy (Sep. 22, 2014) — Green balls of algae washed up on Sydney, Australia's Dee Why Beach. Video provided by Newsy
Powered by NewsLook.com
Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) — The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) — Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins