Featured Research

from universities, journals, and other organizations

YbeY is essential for fitness and virulence of V. cholerae, keeps RNA household in order

Date:
June 5, 2014
Source:
PLOS
Summary:
YbeY is a conserved protein that is present in most bacteria. A new study examines the function of YbeY in the cholera bacterium and reveals critical roles in RNA metabolism in this and other pathogenic bacteria.

YbeY is a conserved protein that is present in most bacteria. A study published on June 5th in PLOS Pathogens examines the function of YbeY in the cholera bacterium and reveals critical roles in RNA metabolism in this and other pathogenic bacteria.

Related Articles


Graham Walker, from the Massachusetts Institute of Technology, USA, and colleagues previously studied E. coli YbeY and found that it acts as an "RNase" -- a protein that deliberately and specifically cuts RNA molecules and thereby regulates their availability and activity. Turning to Vibrio cholerae to examine the role of YbeY in disease-causing pathogens, they now report that YbeY is essential in this pathogen, critical for cell fitness and general stress tolerance, and involved in the regulation of different classes of RNA targets.

Like in higher organisms, genetic information contained in the DNA of bacteria gets "transcribed" into RNA molecules. Some of these RNAs serve as templates for proteins, others form part of the bacterial protein factories (so-called ribosomes), and yet another group consists of small regulatory RNAs that modulate cellular functions of the bacteria and their hosts. The researchers demonstrate that YbeY is needed in generating the components for functional ribosomes, for their assembly, and for ribosome quality control -- eliminating defective protein factories before they turn out faulty products.

In addition, they find that YbeY targets virulence-associated small regulatory RNAs. Consistent with these functions, reducing the amount of YbeY makes V. cholerae less harmful (or virulent) in a mouse cholera model. The researchers also show that YbeY belongs to a set of conserved RNases that are essential in many different pathogens, including Streptococcus pneumoniae and Mycobacterium tuberculosis.

They conclude that "although functionally associated with a well-established antibiotic target, the ribosome, YbeY is so far unexploited as a drug target and its use . . . might lead to the discovery of completely novel antibiotic scaffolds" and suggest that "considering YbeY's high level of conservation, its essential nature in many pathogens, and its ability to sensitize pathogens by disrupting stress tolerance and virulence, a YbeY-specific antibiotic could have broad-spectrum antimicrobial activity."


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maarten Vercruysse, Caroline Kφhrer, Bryan W. Davies, Markus F. F. Arnold, John J. Mekalanos, Uttam L. RajBhandary, Graham C. Walker. The Highly Conserved Bacterial RNase YbeY Is Essential in Vibrio cholerae, Playing a Critical Role in Virulence, Stress Regulation, and RNA Processing. PLoS Pathogens, 2014; 10 (6): e1004175 DOI: 10.1371/journal.ppat.1004175

Cite This Page:

PLOS. "YbeY is essential for fitness and virulence of V. cholerae, keeps RNA household in order." ScienceDaily. ScienceDaily, 5 June 2014. <www.sciencedaily.com/releases/2014/06/140605183605.htm>.
PLOS. (2014, June 5). YbeY is essential for fitness and virulence of V. cholerae, keeps RNA household in order. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2014/06/140605183605.htm
PLOS. "YbeY is essential for fitness and virulence of V. cholerae, keeps RNA household in order." ScienceDaily. www.sciencedaily.com/releases/2014/06/140605183605.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Praying Mantis Looks Long Before It Leaps

Praying Mantis Looks Long Before It Leaps

Reuters - Innovations Video Online (Mar. 5, 2015) — Slowed-down footage of the leaps of praying mantises show the insect&apos;s extraordinary precision, say researchers. Video provided by Reuters
Powered by NewsLook.com
Octopus Grabs Camera and Turns It Around On Photographer

Octopus Grabs Camera and Turns It Around On Photographer

Buzz60 (Mar. 5, 2015) — A photographer got the shot of a lifetime, or rather an octopus did, when it grabbed the camera and turned it around to take an amazing picture of the photographer. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
Ringling Bros. Eliminating Elephant Acts

Ringling Bros. Eliminating Elephant Acts

AP (Mar. 5, 2015) — The Ringling Bros. and Barnum & Bailey Circus is ending its iconic elephant acts. The circus&apos; parent company, Feld Entertainment, told the AP exclusively that the acts will be phased out by 2018 over growing public concern about the animals. (March 5) Video provided by AP
Powered by NewsLook.com
Raw: Tourists Visit Rare Grey Whales in Mexico

Raw: Tourists Visit Rare Grey Whales in Mexico

AP (Mar. 4, 2015) — Once nearly extinct, grey whales now migrate in their thousands to Mexico&apos;s Vizcaino reserve in Baja California, in search of warmer waters to mate and give birth. Tourists flock to the reserve to see the whales, measuring up to 49 feet long. (March 4) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins