Featured Research

from universities, journals, and other organizations

Limb regeneration: Do salamanders hold the key?

Date:
June 19, 2014
Source:
University College London
Summary:
The secret of how salamanders successfully regrow body parts is being unravelled by researchers in a bid to apply it to humans. For the first time, researchers have found that the 'ERK pathway' must be constantly active for salamander cells to be reprogrammed, and hence able to contribute to the regeneration of different body parts.

This is an image of a salamander (the newt Notophthalmus viridescens).
Credit: UCL

The secret of how salamanders successfully regrow body parts is being unravelled by UCL researchers in a bid to apply it to humans.

Related Articles


For the first time, researchers have found that the 'ERK pathway' must be constantly active for salamander cells to be reprogrammed, and hence able to contribute to the regeneration of different body parts.

The team identified a key difference between the activity of this pathway in salamanders and mammals, which helps us to understand why humans can't regrow limbs and sheds light on how regeneration of human cells can be improved.

The study published in Stem Cell Reports today, demonstrates that the ERK pathway is not fully active in mammalian cells, but when forced to be constantly active, gives the cells more potential for reprogramming and regeneration. This could help researchers better understand diseases and design new therapies.

Lead researcher on the study, Dr Max Yun (UCL Institute of Structural and Molecular Biology) said: "While humans have limited regenerative abilities, other organisms, such as the salamander, are able to regenerate an impressive repertoire of complex structures including parts of their hearts, eyes, spinal cord, tails, and they are the only adult vertebrates able to regenerate full limbs.

We're thrilled to have found a critical molecular pathway, the ERK pathway, that determines whether an adult cell is able to be reprogrammed and help the regeneration processes. Manipulating this mechanism could contribute to therapies directed at enhancing regenerative potential of human cells."

The ERK pathway is a way for proteins to communicate a signal from the surface of a cell to the nucleus which contains the cell's genetic material. Further research will focus on understanding how this important pathway is regulated during limb regeneration, and which other molecules are involved in the process.


Story Source:

The above story is based on materials provided by University College London. Note: Materials may be edited for content and length.


Journal Reference:

  1. MaximinaH. Yun, PhillipB. Gates, JeremyP. Brockes. Sustained ERK Activation Underlies Reprogramming in Regeneration-Competent Salamander Cells and Distinguishes Them from Their Mammalian Counterparts. Stem Cell Reports, 2014; DOI: 10.1016/j.stemcr.2014.05.009

Cite This Page:

University College London. "Limb regeneration: Do salamanders hold the key?." ScienceDaily. ScienceDaily, 19 June 2014. <www.sciencedaily.com/releases/2014/06/140619125218.htm>.
University College London. (2014, June 19). Limb regeneration: Do salamanders hold the key?. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2014/06/140619125218.htm
University College London. "Limb regeneration: Do salamanders hold the key?." ScienceDaily. www.sciencedaily.com/releases/2014/06/140619125218.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dog Flu Spreading in Midwestern States

Dog Flu Spreading in Midwestern States

AP (Apr. 17, 2015) Dog flu is spreading in several Midwestern states. Dog daycare centers and veterinary offices are taking precautions. (April 17) Video provided by AP
Powered by NewsLook.com
Raw: Rare Whale Spotted in Gulf of Mexico

Raw: Rare Whale Spotted in Gulf of Mexico

AP (Apr. 17, 2015) Researchers from the E/V Nautilus had quite a surprise Tuesday, when a curious sperm whale swam around their remotely operated vehicle in the Gulf of Mexico. Cameras captured the encounter. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins