Featured Research

from universities, journals, and other organizations

Genes that contribute to radiation resistance identified

Date:
July 21, 2014
Source:
American Society for Microbiology
Summary:
Forty-six genes in Escherichia coli have been discovered that are necessary for its survival at exceptionally high levels of radiation, researchers report in a new article. "The research has revealed new pathways of cellular self-repair, including DNA pathways that in humans that may help protect us from cancer," says a corresponding author.

A team of researchers from the University of Wisconsin has identified 46 genes in Escherichia coli that are necessary for its survival at exceptionally high levels of radiation. The paper appears ahead of print in the Journal of Bacteriology.

Related Articles


"The research has revealed new pathways of cellular self-repair, including DNA pathways that in humans that may help protect us from cancer," says corresponding author Michael M. Cox.

High doses of radiation are deadly not only to humans, plants, and animals, but to microbial cells generally. Nonetheless, certain bacteria, notably Deinococcus radiodurans, are highly resistant to high level radiation. E. coli normally lacks such radiation resistance, but resistant strains were developed by subjecting them to increasing levels of radiation, and harvesting the survivors of each generation.

The 46 genes did not result from the mutations created under high radiation levels, but rather genes that exist in the normal, wild-type E. coli. The results reinforce the notion that survival after high doses of ionizing radiation does not depend on a single mechanism or process, but instead is multifaceted.

"We established a role for genes involved in processes as diverse as central metabolism and the synthesis and maintenance of the cell wall in radiation survival," says Cox. "Perhaps most important, we identified eight genes of unknown function that play substantial roles in radiation survival."

The benefits of this research and its progeny could be substantial, says Cox. "Our understanding of how cells deal with ionizing radiation is very rudimentary. Our work provides an expanded map of the cellular functions that are most directly involved in ameliorating the effects of ionizing radiation. It has revealed some potentially new pathways by which cells repair their DNA and more generally repair their cellular proteins and other components after exposure to high levels of radiation."

One gene, previously of unknown function, has a role in repairing double strand breaks in DNA. "The gene is related to a human gene called XPB, and it may help elucidate some key DNA repair pathways in humans that help protect us from cancer," says Cox.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rose T. Byrne, Stefanie H. Chen, Elizabeth A. Wood, Eric L. Cabot, and Michael M. Cox. Surviving extreme exposure to ionizing radiation: Escherichia coli genes and pathways. Journal of Bacteriology, July 2014 DOI: 10.1128/JB.01589-14

Cite This Page:

American Society for Microbiology. "Genes that contribute to radiation resistance identified." ScienceDaily. ScienceDaily, 21 July 2014. <www.sciencedaily.com/releases/2014/07/140721123825.htm>.
American Society for Microbiology. (2014, July 21). Genes that contribute to radiation resistance identified. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2014/07/140721123825.htm
American Society for Microbiology. "Genes that contribute to radiation resistance identified." ScienceDaily. www.sciencedaily.com/releases/2014/07/140721123825.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins