Featured Research

from universities, journals, and other organizations

Scissoring the lipids: New strategy of disconnecting molecules may lead to tuberculosis vaccine

Date:
July 28, 2014
Source:
University of Bristol
Summary:
A new strategy that enables molecules to be disconnected essentially anywhere, even remote from functionality, is described by researchers in a new article. The method is now being developed to explore the possibility of creating a tuberculosis (TB) vaccine. The organic synthesis strategy involves a new method for combining smaller fragments together in which there is no obvious history in the product of their genesis.

A new strategy which enables molecules to be disconnected essentially anywhere, even remote from functionality, is described by researchers from the University of Bristol in Nature Chemistry. The method is now being developed to explore the possibility of creating a tuberculosis (TB) vaccine.

The organic synthesis strategy, developed by Professor Varinder Aggarwal and Dr Ramesh Rasappan in the School of Chemistry, involves a new method for combining smaller fragments together in which there is no obvious history in the product of their genesis.

The paper describes not only this new strategy, but also its application to the shortest known synthesis, just 14 steps, of hydroxyphthioceranic acid, a key component of the cell wall lipid of the virulent mycobacterium tuberculosis.

Professor Aggarwal said: "Tuberculosis bacteria (TB) have an extraordinary thick lipid coat which acts as an impenetrable waxy barrier to cytotoxic agents, making it especially challenging to combat. Vaccination would be an ideal solution against TB and the lipid coat has been identified as a potential antigen. This requires the synthesis of the complex lipid which is composed of a disaccharide sugar core along with the complex chiral lipid, hydroxyphthioceranic acid."

In a collaborative project funded by the Gates Foundation, the method is now being scaled up to explore the possibility of creating a TB vaccine based on the cell wall sulfolipid.


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ramesh Rasappan, Varinder K. Aggarwal. Synthesis of hydroxyphthioceranic acid using a traceless lithiation–borylation–protodeboronation strategy. Nature Chemistry, 2014; DOI: 10.1038/nchem.2010

Cite This Page:

University of Bristol. "Scissoring the lipids: New strategy of disconnecting molecules may lead to tuberculosis vaccine." ScienceDaily. ScienceDaily, 28 July 2014. <www.sciencedaily.com/releases/2014/07/140728113359.htm>.
University of Bristol. (2014, July 28). Scissoring the lipids: New strategy of disconnecting molecules may lead to tuberculosis vaccine. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2014/07/140728113359.htm
University of Bristol. "Scissoring the lipids: New strategy of disconnecting molecules may lead to tuberculosis vaccine." ScienceDaily. www.sciencedaily.com/releases/2014/07/140728113359.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins