Featured Research

from universities, journals, and other organizations

Scientists sequence complete genome of E. coli strain responsible for food poisoning

Date:
September 2, 2014
Source:
University of California - San Diego
Summary:
The first complete genome sequencing of a strain of E. coli that is a common cause of outbreaks of food poisoning in the United States has been sequenced by scientists. Although the E. coli strain EDL933 was first isolated in the 1980s, it gained national attention in 1993 when it was linked to an outbreak of food poisoning from Jack-in-the-Box restaurants in the western United States.

Researchers at the University of California, San Diego have produced the first complete genome sequencing of a strain of E. coli that is a common cause of outbreaks of food poisoning in the United States. Although the E. coli strain EDL933 was first isolated in the 1980s, it gained national attention in 1993 when it was linked to an outbreak of food poisoning from Jack-in-the-Box restaurants in the western United States. Their paper published online Aug. 14 in the journal Genome Announcements reports the full, complete sequence with no gaps. Their analysis includes so-called jumping genes that can move around the same genome, sometimes causing damage to individual genes or enabling antibiotic resistance.

Related Articles


"With a complete genome sequence, we can now pinpoint the precise location of all such elements, which might help to track and treat future outbreaks," said Ramy Aziz, the senior author on the paper. Aziz led the research as a visiting scientist working in Bernhard Palsson's Systems Biology Research Group at UC San Diego Jacobs School of Engineering. Aziz is also a professor at Cairo University in Egypt.

The genome sequence for this historical strain was first published in 2001, but there were many gaps in the genome that could not be closed with the sequencing technology available to scientists in 2001. Given the importance of this strain as a major cause of food poisoning, Palsson's Systems Biology Research Group recently sequenced its genome using a combination of sequencing data from instruments made by Pacific Biosciences and Illumina.

"New sequencing and assembly methods are enabling a full expose of pesky pathogens; there is no place to hide genetic characteristics anymore. The full genetic delineation of multiple pathogenic strains is likely to not only improve our understanding of their characteristics, but to find and exploit their vulnerabilities, said Palsson, the Galletti Professor of Bioengineering at UC San Diego.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Latif, H. J. Li, P. Charusanti, B. O. Palsson, R. K. Aziz. A Gapless, Unambiguous Genome Sequence of the Enterohemorrhagic Escherichia coli O157:H7 Strain EDL933. Genome Announcements, 2014; 2 (4): e00821-14 DOI: 10.1128/genomeA.00821-14

Cite This Page:

University of California - San Diego. "Scientists sequence complete genome of E. coli strain responsible for food poisoning." ScienceDaily. ScienceDaily, 2 September 2014. <www.sciencedaily.com/releases/2014/09/140902094315.htm>.
University of California - San Diego. (2014, September 2). Scientists sequence complete genome of E. coli strain responsible for food poisoning. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/09/140902094315.htm
University of California - San Diego. "Scientists sequence complete genome of E. coli strain responsible for food poisoning." ScienceDaily. www.sciencedaily.com/releases/2014/09/140902094315.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins