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Reduced Mitochondrial Function Important Mechanism In Aging

Date:
May 31, 2004
Source:
Swedish Research Council
Summary:
Scientists at the Karolinska Institute have found that changes in the "powerhouse" of cells, the mitochondria, play a key role in aging.
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Scientists at the Karolinska Institute have found that changes in the "powerhouse" of cells, the mitochondria, play a key role in aging. The findings are being published in this week's issue of the journal Nature.

Mitochondria, which provide energy to cells, have their own set of DNA. Mutations of mitochondrial DNA increase with age, but until now no one knew whether this is a result of aging or a cause of aging. New research findings now indicate that the latter is the case.

Mice with a deficient capacity to correct mutations in mitochondrial DNA acquired an increased number of mutations and proved to age considerably earlier than normal. They lived an average of 10 to 12 months compared with the normal 2 or 3 years. These mice also developed several typical signs of premature aging, such as osteoporosis, weight loss, hair loss, anemia, reduced fertility, and heart muscle disorders.

The findings reveal fundamental biological mechanisms that lie behind the aging process. This knowledge paves the way for the possibility of slowing down aging and treating pathological changes that arise in connection with aging by protecting mitochondrial DNA from damage.

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The article is published in Nature, May 27, 2004, pp. 417–423.It is illustrated by a picture on the cover of Nature and commentated by two scientists from the University of Washington, Seattle.

Publication:Premature aging in mice expressing defective mitochondrial DNA polymeraseNature (2004) 429: 417-423,

Authors:Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson N-G.


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Swedish Research Council. "Reduced Mitochondrial Function Important Mechanism In Aging." ScienceDaily. ScienceDaily, 31 May 2004. <www.sciencedaily.com/releases/2004/05/040527234844.htm>.
Swedish Research Council. (2004, May 31). Reduced Mitochondrial Function Important Mechanism In Aging. ScienceDaily. Retrieved May 22, 2017 from www.sciencedaily.com/releases/2004/05/040527234844.htm
Swedish Research Council. "Reduced Mitochondrial Function Important Mechanism In Aging." ScienceDaily. www.sciencedaily.com/releases/2004/05/040527234844.htm (accessed May 22, 2017).

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