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When Does Being Obese Not Lead To Diabetes? When Mice Lack Osteopontin

Date:
September 10, 2007
Source:
Journal of Clinical Investigation
Summary:
Obesity is one of the biggest risk factors for type 2 diabetes. One reason for this is thought to be the chronic inflammation characterized by macrophage infiltration into adipose tissue that accompanies obesity, because it has been linked to the development of insulin resistance (which in turn often leads to type 2 diabetes).
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Obesity is one of the biggest risk factors for type 2 diabetes.

One reason for this is thought to be the chronic inflammation characterized by macrophage infiltration into adipose tissue that accompanies obesity, because it has been linked to the development of insulin resistance (which in turn often leads to type 2 diabetes).

New data generated in mice by Dennis Bruemmer and colleagues at the University of Kentucky College of Medicine, Lexington, provides support for this hypothesis.

Osteopontin is an extracellular matrix protein and proinflammatory cytokine that is required for macrophage infiltration of a tissue during an immune response. Bruemmer and colleagues found that although mice lacking osteopontin became obese when fed a high-fat diet, they did not become as insulin resistant as normal mice fed the same diet.

This decrease in insulin resistance was associated with decreased accumulation of macrophages in the adipose tissue leading the authors to conclude that osteopontin has a key role in linking obesity to the development of insulin resistance in mice.

Article: "Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice," Journal of Clinical Investigation


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Journal of Clinical Investigation. "When Does Being Obese Not Lead To Diabetes? When Mice Lack Osteopontin." ScienceDaily. ScienceDaily, 10 September 2007. <www.sciencedaily.com/releases/2007/09/070907105629.htm>.
Journal of Clinical Investigation. (2007, September 10). When Does Being Obese Not Lead To Diabetes? When Mice Lack Osteopontin. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2007/09/070907105629.htm
Journal of Clinical Investigation. "When Does Being Obese Not Lead To Diabetes? When Mice Lack Osteopontin." ScienceDaily. www.sciencedaily.com/releases/2007/09/070907105629.htm (accessed May 23, 2017).

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