Major Mid-century Influenza Epidemics Caused By Novel Hybrid Viruses

Specifically, the researchers found that the severe influenza epidemics of 1947 and 1951 were caused by genetic reassortment events in which two human influenza viruses of the same H1N1 strain exchanged genetic material, producing a new hybrid virus in both cases.

It has been a mystery why unusually severe epidemics of influenza occur from time to time, such as in 1947 and 1951, when illness and mortality rates exceeded standard epidemic levels. The standard model of human influenza virus evolution holds that major influenza pandemics, the largest of which occurred in 1918, are caused by reassortment between human and avian influenza viruses. But seasonal influenza epidemics, which occur each winter in the United States, do not involve the reassortment of genetic material.

These new findings suggest that the evolution of seasonal influenza is more complex than previously thought, and that multiple forms of the same strain co-circulate and re-assort within a single population, rapidly generating genetically novel viruses with the potential to ignite major epidemics. It is therefore critical that intensive surveillance is undertaken to capture the full extent of influenza genetic diversity that co-circulates at a given time, particularly as an aid to vaccine design.

Journal reference: Nelson MI, Viboud C, Simonsen L, Bennett RT, Griesemer SB, et al. (2008) Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918. PLoS Pathog 4(2): e1000012. doi:10.1371/journal.ppat.1000012 http://www.plospathogens.org/doi/ppat.1000012