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High hepatitis C cure rate seen in trial of 6-week oral drug regimens

Date:
January 12, 2015
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
Thirty-eight of 40 volunteers with hepatitis C virus (HCV) infections who received a combination of three direct-acting oral drugs for six weeks were cured in a recent clinical trial. A six-week course of therapy is half the length of time previously shown to achieve a similar cure rate using two direct-acting oral HCV drugs only.
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Thirty-eight of 40 volunteers with hepatitis C virus (HCV) infections who received a combination of three direct-acting oral drugs for six weeks were cured in a clinical trial conducted at the National Institutes of Health (NIH). A six-week course of therapy is half the length of time previously shown to achieve a similar cure rate using two direct-acting oral HCV drugs only. The trial findings appear in The Lancet.

A group of 20 volunteers received the recently licensed drug sofosbuvir (trade name Sovaldi) along with two other direct-acting oral therapies, ledipasvir and an experimental drug named GS-9669, for six weeks. A second group of 20 volunteers received sofosbuvir, ledipasvir and a different experimental drug, GS-9451, for six weeks. None of the volunteers had been treated previously for their HCV infections, and all tolerated the drug regimens well. In the first group, one volunteer relapsed two weeks after completing therapy, but the remaining 19 people had no detectable HCV when tested 12 weeks after the end of therapy and were deemed cured. In the second group, one volunteer was lost to follow-up, but the remaining 19 had no detectable HCV 12 weeks after the end of therapy and were also deemed cured. A third group of 20 volunteers received just two oral drugs--sofosbuvir and ledipasvir--for 12 weeks. All 20 were cured with that drug regimen.

"This short duration, simple therapy for HCV may prove relevant for the global elimination of hepatitis C, where simple, well-tolerated therapy of short duration is required to ensure adherence," the study authors write.


Story Source:

Materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Content may be edited for style and length.


Journal Reference:

  1. A Kohli et al. Virological response after 6 week triple-drug regimens for hepatitis C: a proof-of-concept phase 2A cohort study. The Lancet, January 2015 DOI: 10.1016/S0140-6736(14)61228-9

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "High hepatitis C cure rate seen in trial of 6-week oral drug regimens." ScienceDaily. ScienceDaily, 12 January 2015. <www.sciencedaily.com/releases/2015/01/150112191340.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2015, January 12). High hepatitis C cure rate seen in trial of 6-week oral drug regimens. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/01/150112191340.htm
NIH/National Institute of Allergy and Infectious Diseases. "High hepatitis C cure rate seen in trial of 6-week oral drug regimens." ScienceDaily. www.sciencedaily.com/releases/2015/01/150112191340.htm (accessed May 23, 2017).

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