Science News
from research organizations

Leaky channels could contribute to unusual heart arrhythmias

Date:
January 26, 2015
Source:
The Rockefeller University Press
Summary:
Leaks are not just problems for plumbers and politicians; researchers reveal how leaky transmembrane channels could cause disruptions in normal heart function. The study suggests that ion leaks in mutant sodium channels might contribute to an unusual set of cardiac arrhythmias.
Share:
FULL STORY

This is an illustration of the cardiac Nav1.5 channel. The red circles indicate the locations of the R222Q and R225W mutations in the voltage-sensing region of domain 1 (DI).
Credit: Moreau et al., 2015

Leaks are not just problems for plumbers and politicians; researchers in Canada reveal how leaky transmembrane channels could cause disruptions in normal heart function. The study, published in The Journal of General Physiology, suggests that ion leaks in mutant sodium channels might contribute to an unusual set of cardiac arrhythmias.

Voltage-gated sodium (Nav) channels are responsible for mediating an "action potential" in muscle cells that leads to contraction. Nav1.5 is the primary Nav channel expressed in the muscle cells of the heart, and Nav1.5 mutations that disrupt its function are associated with many well-defined cardiac arrhythmias. Recent studies have linked two Nav1.5 mutations (R222Q and R225W) to an unusual group of arrhythmias that are associated with dilated cardiomyopathy, a condition in which the heart becomes enlarged and cannot pump blood efficiently.

Oddly enough, the two mutant channels have opposite effects on channel function, with one expected to promote premature firing of the action potential and the other expected to interfere with action potential initiation. It's therefore unclear how they could be linked to similar cardiac pathologies.

In search of a unifying mechanism, Mohamed Chahine and colleagues in Quebec City investigated the properties of the mutant channels. Voltage-gated channels contain four segments called voltage sensor domains (VSDs), which are typically nonconductive and distinct from the regions that make up the channel pore; the R222Q and R225W mutations are both located on one of these VSDs. During initiation of the cardiac action potential, however, when the negative internal charge of the cell becomes positive so that the cell becomes "depolarized," the researchers found that both mutations caused the VSD assume a conformation that created an abnormal pathway allowing positively charged ions to pass through this normally nonconductive region. Moreover, the VSD seemed to become immobilized following depolarizations comparable in length to the cardiac action potential instead of returning to resting position, allowing charged sodium ions to continue leaking into the cell.

Chahine and colleagues think that the resulting overload of sodium ions within the cell could contribute to disruptions in normal cardiac function. And because the ion leak is the only property common to both mutations, their findings suggest that it could be a key mechanism linking them -- and possibly other Nav1.5 mutations in the VSD -- to the atypical group of arrhythmias mixed with dilated cardiomyopathy.


Story Source:

Materials provided by The Rockefeller University Press. Note: Content may be edited for style and length.


Journal Reference:

  1. A. Moreau, P. Gosselin-Badaroudine, L. Delemotte, M. L. Klein, M. Chahine. Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy. The Journal of General Physiology, 2015; 145 (2): 93 DOI: 10.1085/jgp.201411304

Cite This Page:

The Rockefeller University Press. "Leaky channels could contribute to unusual heart arrhythmias." ScienceDaily. ScienceDaily, 26 January 2015. <www.sciencedaily.com/releases/2015/01/150126095327.htm>.
The Rockefeller University Press. (2015, January 26). Leaky channels could contribute to unusual heart arrhythmias. ScienceDaily. Retrieved May 25, 2017 from www.sciencedaily.com/releases/2015/01/150126095327.htm
The Rockefeller University Press. "Leaky channels could contribute to unusual heart arrhythmias." ScienceDaily. www.sciencedaily.com/releases/2015/01/150126095327.htm (accessed May 25, 2017).

RELATED STORIES