New method shrinks metastatic ovarian cancer and reduces chemotherapy dose

"We hope that this study will lead to novel treatment approaches for women diagnosed with advanced stage ovarian cancer," said Jim Petrik, Ph.D., a researcher involved in the work from the Department of Biomedical Sciences at the University of Guelph in Guelph, Ontario. "The use of anti-angiogenic therapy, combined with metronomic chemotherapy, has the potential to significantly improve our ability to treat advanced stage ovarian cancer while simultaneously reducing the treatment effects for women diagnosed with this disease."

To make their discovery, Petrik and colleagues injected mouse ovarian cancer cells into the ovaries of mice. The resulting tumors were allowed to grow until they were similar to those in patients with advanced ovarian cancer, including the spread of small tumors throughout the abdomen. Pre-treatment with 3TSR improved chemotherapy drug delivery and when combined with low-dose chemotherapy, resulted in the most significant tumor regression and survival. This approach caused tumor shrinkage and resulted in destruction of abnormal, dysfunctional tumor blood vessels. The result was a smaller tumor, with improved blood supply. Researchers were then able to exploit this enhanced blood supply to improve chemotherapy drug delivery to the tumor and were able to treat with very small amounts of drug, with excellent clinical effect.

"When Judah Folkman first proposed the idea that tumor growth depended on angiogenesis," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "he was dismissed by his peers. Now, of course, it's a given fact and this new work extends the concept. It shows that biologically-based inhibitors of angiogenesis work together with chemotherapy to bring us closer to tumor cures than ever before."