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Cough suppressant improves blood sugar levels in diabetes mellitus

Date:
March 17, 2015
Source:
Medical University of Vienna
Summary:
The active ingredient dextromethorphan, which is contained in many over-the-counter cough remedies, has been shown to improve blood sugar levels in type 2 diabetes (diabetes mellitus), a study concludes.
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The active ingredient dextromethorphan, which is contained in many over-the-counter cough remedies, has been shown to improve blood sugar levels in type 2 diabetes (diabetes mellitus). That was the finding of a recent international study, in which the Center for Physiology and Pharmacology of MedUni Vienna played a significant part and which has now been published in the leading medical journal "Nature Medicine."

Using electrophysiological methods to measure electrical currents through cell membranes, the research group at the Institute for Physiology and Pharmacology, led by Marjan Slak Rupnik, showed that dextromethorphan extends the periods of electrical activity in beta cells. It is precisely during these periods, so-called bursts, that the cells secrete insulin.

The scientists demonstrated that, via so-called NMDA receptors, the active ingredient stimulated the pancreatic beta cells to secrete more insulin at raised blood sugar levels. This brought about an improvement in blood sugar, whilst at the same time reducing so-called sugar spikes, that is phases with particularly high blood glucose concentrations.

Also of benefit for type 1 diabetics

Slak Rupnik: "Our studies also indicate that the tested cough suppressant protects the beta cells from cell death, which would also be very beneficial for type 1 diabetics." Their diabetes worsens appreciably over the course of the illness so that -- despite an improvement in blood sugar levels directly after the start of insulin therapy -- they have a constantly high insulin requirement. This is thought to be due to the beta cells dying off or at least gradually producing less insulin, amongst other things. Further studies are now required to clarify whether the cough suppressant actually protects the beta cells if it is used in conjunction with conventional diabetes therapy.


Story Source:

Materials provided by Medical University of Vienna. Note: Content may be edited for style and length.


Journal Reference:

  1. Jan Marquard, Silke Otter, Alena Welters, Alin Stirban, Annelie Fischer, Jan Eglinger, Diran Herebian, Olaf Kletke, Maša Skelin Klemen, Andraž Stožer, Stephan Wnendt, Lorenzo Piemonti, Martin Köhler, Jorge Ferrer, Bernard Thorens, Freimut Schliess, Marjan Slak Rupnik, Tim Heise, Per-Olof Berggren, Nikolaj Klöcker, Thomas Meissner, Ertan Mayatepek, Daniel Eberhard, Martin Kragl, Eckhard Lammert. Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nature Medicine, 2015; DOI: 10.1038/nm.3822

Cite This Page:

Medical University of Vienna. "Cough suppressant improves blood sugar levels in diabetes mellitus." ScienceDaily. ScienceDaily, 17 March 2015. <www.sciencedaily.com/releases/2015/03/150317092833.htm>.
Medical University of Vienna. (2015, March 17). Cough suppressant improves blood sugar levels in diabetes mellitus. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2015/03/150317092833.htm
Medical University of Vienna. "Cough suppressant improves blood sugar levels in diabetes mellitus." ScienceDaily. www.sciencedaily.com/releases/2015/03/150317092833.htm (accessed May 28, 2017).

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