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Drug discovery
In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed. In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge.
The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.
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Health & Medicine News
November 9, 2025
Nov. 9, 2025 — A hospital in Thailand created a quick-action dialysis protocol for patients with metformin-associated lactic acidosis, a dangerous reaction to a common diabetes drug. The program sharply reduced deaths and sped up treatment times. Awareness also ...
Nov. 9, 2025 — Millions struggle with depression and anxiety, often enduring long waits for effective treatment. Scientists in Sweden, Denmark, and Germany are developing a genetic test to predict which medications will actually work. Using polygenic risk scores, ...
Nov. 8, 2025 — Scientists found that DNA’s phosphate groups can direct chemical reactions to make the correct mirror-image form of drug molecules. This breakthrough simplifies chiral drug production, reducing waste and energy use. Using a new “PS scanning” ...
Nov. 8, 2025 — Sertraline (Zoloft) may relieve emotional symptoms of depression and anxiety within two weeks, while physical side effects stabilize later. The research highlights how antidepressants can act on specific symptom networks rather than uniformly across ...
Nov. 8, 2025 — Researchers have identified special immune cells in the brain that help slow Alzheimer’s. These microglia work to reduce inflammation and block the spread of harmful proteins. They appear to protect memory and brain health, offering a promising ...
Nov. 8, 2025 — Aalto University scientists have created a laser-based treatment that uses gentle heat to stop the progression of dry macular degeneration. The approach stimulates the eye’s natural cleanup and repair systems to protect against ...
Nov. 8, 2025 — A decade-long review by George Mason University researchers reveals growing evidence that neonicotinoid insecticides—the world’s most widely used class of pesticides—may harm male reproductive health. The findings, based on 21 animal studies, ...
Nov. 8, 2025 — New research suggests the COVID-19 vaccine could help children with eczema stay healthier overall. Vaccinated kids had lower rates of infections and allergies, including asthma and rhinitis, compared with unvaccinated peers. Experts believe the ...
Nov. 7, 2025 — Researchers found that the body’s natural recycling system, the lysosome, plays a vital role in removing the protein that drives premature aging. When this system breaks down, aging speeds up. By reactivating it, scientists were able to help cells ...
Nov. 7, 2025 — A Stanford-led team has replaced toxic pre-transplant chemotherapy with a targeted antibody, allowing children with Fanconi anemia to receive stem cell transplants safely. The antibody, briquilimab, removes diseased stem cells without radiation, ...
Nov. 7, 2025 — Prenatal exposure to the insecticide chlorpyrifos causes widespread brain abnormalities and poorer motor skills in children. Even after a residential ban, ongoing agricultural use continues to endanger developing ...
Nov. 7, 2025 — Scientists have pinpointed a “Big Bang” moment in bowel cancer—when cells first evade the immune system. This early immune escape locks in how the cancer will behave as it grows. The discovery could help predict which patients respond to ...
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Nov. 7, 2025 — Rockefeller scientists uncovered how hair follicle stem cells can switch from growing hair to repairing skin when nutrients run low. The key lies in serine, an amino acid that activates a stress ...
Nov. 7, 2025 — Almost 20% of packaged foods and beverages in the US contain synthetic dyes, often paired with excessive sugar to attract children. These additives have been linked to behavioral issues, yet remain ...
Nov. 7, 2025 — An extract from a desert berry used in traditional Chinese medicine restored insulin function and stabilized metabolism in diabetic mice. The findings hint at a powerful natural alternative for ...
Nov. 6, 2025 — Miniature antibodies from camels and llamas can slip into the brain more easily than conventional drugs, offering a new way to treat disorders like Alzheimer’s and schizophrenia. Researchers say ...
Nov. 6, 2025 — Scientists have discovered a surprising benefit of the acne drug doxycycline: it may lower the risk of schizophrenia. Teens prescribed the antibiotic were about one-third less likely to develop the ...
Nov. 6, 2025 — A newly identified disorder, MINA syndrome, results from a mutation in the NAMPT protein that deprives motor neurons of energy, leading to severe movement problems. The discovery not only deepens ...
Nov. 6, 2025 — Novo Nordisk’s oral semaglutide 25 mg achieved up to 16.6% weight loss in a landmark study, rivaling injectable Wegovy. The pill also improved cardiovascular risk factors and physical activity ...
Nov. 6, 2025 — Weill Cornell researchers uncovered how free radicals from astrocyte mitochondria can fuel dementia. Using new compounds that target these radicals at their source, they slowed brain inflammation and ...
Nov. 6, 2025 — Researchers have created a bioinspired gel that can regenerate tooth enamel by mimicking natural growth processes. The fluoride-free material forms a mineral-rich layer that restores enamel’s ...
Nov. 5, 2025 — A Northwestern team transformed a common chemotherapy drug into a powerful, targeted cancer therapy using spherical nucleic acids. The redesign dramatically boosted drug absorption and cancer-killing ...