Science News
from research organizations

Inactive tumor suppressor gene discovered in lung cancer

Date:
April 14, 2015
Source:
IDIBELL-Bellvitge Biomedical Research Institute
Summary:
The PARD3 gene has been identified by researchers as a tumor suppressor that is inactivated in lung cancer squamous type. PARD3 gene encodes a protein that regulates cell polarization and cell junctions. When the gene is inactivated, errors occur in this cell orientation and in contact with neighboring cells. "Any change affecting this structure promotes tumor development," said a researcher.
Share:
FULL STORY

Correct tight junctions between cells labeled in yellow due to the presence of the protein PARD3.
Credit: IDIBELL

Researchers at Genes and Cancer group at Bellvitge Biomedical Research Institute (IDIBELL), led by Montse Sanchez-Cespedes, have identified the PARD3 gene as a tumor suppressor that is inactivated in lung cancer squamous type. The results of the study have been published in Cancer Research.

Correct polarization (orientation in space) of bronchial epithelial cells is essential for the maintenance and proper development of this tissue under normal conditions.

PARD3 gene encodes a protein that regulates cell polarization and cell junctions. When the gene is inactivated, errors occur in this cell orientation and in contact with neighboring cells. "Any change affecting this structure promotes tumor development," said the researcher Montse Sanchez-Cespedes.

Tumor invasion and metastasis

By restoring protein encoded by PARD3 levels, both, cell lines and animal models of mice, we observed that regulating de novo polarization of cells, significantly reduced the risk of metastasis.

Lung cancer

Lung cancer is one of the tumors having higher mortality rates worldwide. Only in Spain each year about 20,000 people die from this cause. The high mortality rate is mainly due to late diagnosis of the disease, when it is already in an advanced stage.

Late detection and lack of effective therapies make the probability of survival of patients with lung cancer is very low. Overall, only 10% and 15% of patients survive more than five years after detection. The origin of more than 80% of cases is the consumption of snuff. The squamous lung cancer and lung adenocarcinoma type are the two most common types of lung tumor.


Story Source:

Materials provided by IDIBELL-Bellvitge Biomedical Research Institute. Note: Content may be edited for style and length.


Journal Reference:

  1. E. Bonastre, S. Verdura, I. Zondervan, F. Facchinetti, S. Lantuejoul, M. D. Chiara, J. P. Rodrigo, J. Carretero, E. Condom, A. Vidal, D. Sidransky, A. Villanueva, L. Roz, E. Brambilla, S. Savola, M. Sanchez-Cespedes. PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion. Cancer Research, 2015; 75 (7): 1287 DOI: 10.1158/0008-5472.CAN-14-2444

Cite This Page:

IDIBELL-Bellvitge Biomedical Research Institute. "Inactive tumor suppressor gene discovered in lung cancer." ScienceDaily. ScienceDaily, 14 April 2015. <www.sciencedaily.com/releases/2015/04/150414100954.htm>.
IDIBELL-Bellvitge Biomedical Research Institute. (2015, April 14). Inactive tumor suppressor gene discovered in lung cancer. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/04/150414100954.htm
IDIBELL-Bellvitge Biomedical Research Institute. "Inactive tumor suppressor gene discovered in lung cancer." ScienceDaily. www.sciencedaily.com/releases/2015/04/150414100954.htm (accessed May 23, 2017).

RELATED STORIES