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Using big data to help the tiniest patients

Date:
April 27, 2015
Source:
Baylor Scott & White Health
Summary:
An increasing number of babies across the country are born addicted to opioids and require intensive care, according to a study analyzing MEDNAX Clinical Data Warehouse statistics from 299 neonatal intensive care units (NICUs) around the United States.
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An increasing number of babies across the country are born addicted to opioids and require intensive care, according to a study analyzing MEDNAX Clinical Data Warehouse statistics from 299 neonatal intensive care units (NICUs) around the United States.

The study results are reported in a paper authored by a Baylor researcher and published online by the New England Journal of Medicine. The illness, called "neonatal abstinence syndrome" (NAS), is a drug withdrawal syndrome that most commonly occurs after in utero exposure to opioids. It can lead to seizures, difficulty feeding, respiratory complications and low-birth-weight in affected infants.

The study published by the NEJM, titled "Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs," directly addressed the ICU care of these infants and found that NAS is responsible for a substantial and growing portion of resources dedicated to critically ill neonates in NICUs nationwide.

Dr. Veeral N. Tolia, a neonatologist on staff at Baylor University Medical Center at Dallas, led a team of researchers from U.S. hospitals that determined that between 2004 and 2013 the rate of NICU admissions nationwide for NAS increased almost fourfold, from seven to 27 cases per 1000 infants. The research also found that the length of hospitalization increased by more than 40 percent from 13 to 19 days. The total percentage of NICU days attributed to NAS increased by more than 500 percent, with eight centers reporting one in five of all NICU days devoted to care of these infants in 2013.

The team also found that a substantial number of these infants presented after maternal exposure to prescription opioid pain relievers, a class of medication that the Food and Drug Administration (FDA) recently has chosen to regulate more tightly. The study found that among these NICU patients, treatment with medication was common, occurring in 87 percent of the infants from 2012-2013.

This is also problematic because of the scarce research about the best way to care for these infants. None of the commonly used medications are FDA approved for treating NAS and there is substantial variability in how these infants are treated.


Story Source:

Materials provided by Baylor Scott & White Health. Note: Content may be edited for style and length.


Journal Reference:

  1. Veeral N. Tolia, Stephen W. Patrick, Monica M. Bennett, Karna Murthy, John Sousa, P. Brian Smith, Reese H. Clark, Alan R. Spitzer. Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs. New England Journal of Medicine, 2015; 150426153016002 DOI: 10.1056/NEJMsa1500439

Cite This Page:

Baylor Scott & White Health. "Using big data to help the tiniest patients." ScienceDaily. ScienceDaily, 27 April 2015. <www.sciencedaily.com/releases/2015/04/150427101321.htm>.
Baylor Scott & White Health. (2015, April 27). Using big data to help the tiniest patients. ScienceDaily. Retrieved April 28, 2017 from www.sciencedaily.com/releases/2015/04/150427101321.htm
Baylor Scott & White Health. "Using big data to help the tiniest patients." ScienceDaily. www.sciencedaily.com/releases/2015/04/150427101321.htm (accessed April 28, 2017).