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Alzheimer protein's structure may explain its toxicity

Date:
May 7, 2015
Source:
University of Illinois at Chicago
Summary:
The molecular structure of one of the proteins in the fine fibers of the brain plaques that are a hallmark of Alzheimer's disease, researchers have found. This molecule, called amyloid beta-42, is toxic to nerve cells and is believed to provoke the disease cascade.
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"S" structure of amyloid beta-42 with salt bridge in red and blue.
Credit: Yoshitaka Ishii

Researchers at the University of Illinois at Chicago have determined the molecular structure of one of the proteins in the fine fibers of the brain plaques that are a hallmark of Alzheimer's disease. This molecule, called amyloid beta-42, is toxic to nerve cells and is believed to provoke the disease cascade.

The study is online in the journal Nature Structural and Molecular Biology.

Knowing the physical structure of the 42 amino acid-long form of amyloid beta in the fibers is key to understanding how it folds up improperly and aggregates into toxic plaques, says Yoshitaka Ishii, UIC professor of chemistry and principal investigator on the study.

Ishii and his colleagues found that amyloid beta-42 in amyloid fibrils forms three flat structures (called beta sheets) that turn back and forth to layer over each other in an"S" pattern. They also found that the final amino acid on the protein forms a "salt bridge" with an amino acid at the first turn of the S, stabilizing the structure. A salt bridge is a bond between positive- and negative-charged molecules or parts of a molecule.

The 3-D structure is strikingly different from that of amyloid beta-40, a chemically similar and more abundant protein also linked to Alzheimer's. Amyloid beta-40 lacks the final amino acid that carries the negative charge needed to form the salt bridge. "This explains why amyloid beta-42 doesn't interact with amyloid beta-40, or recruit it into the plaques that are toxic to nerve cells," Ishii said.

The structural features and folding behavior of amyloid beta-42 "offer a new perspective on amyloid propagation in Alzheimer's disease and, perhaps, other neurodegenerative disease," said Ishii. Drugs designed to act against amyloid beta-40, he said, "may not work well against the more toxic amyloid beta-42."

The chemical nature of amyloid beta-42 -- especially its extreme aversion to water -- posed a formidable challenge to chemists and structural biologists, Ishii said. "There are a number of laboratories that have been working on this problem, and I am very proud of the work of my graduate student Yiling Xiao in elucidating its structure." Xiao is first author on the study.


Story Source:

Materials provided by University of Illinois at Chicago. Original written by Jeanne Galatzer-Levy. Note: Content may be edited for style and length.


Journal Reference:

  1. Yiling Xiao, Buyong Ma, Dan McElheny, Sudhakar Parthasarathy, Fei Long, Minako Hoshi, Ruth Nussinov, Yoshitaka Ishii. Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease. Nature Structural & Molecular Biology, 2015; DOI: 10.1038/nsmb.2991

Cite This Page:

University of Illinois at Chicago. "Alzheimer protein's structure may explain its toxicity." ScienceDaily. ScienceDaily, 7 May 2015. <www.sciencedaily.com/releases/2015/05/150507155852.htm>.
University of Illinois at Chicago. (2015, May 7). Alzheimer protein's structure may explain its toxicity. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/05/150507155852.htm
University of Illinois at Chicago. "Alzheimer protein's structure may explain its toxicity." ScienceDaily. www.sciencedaily.com/releases/2015/05/150507155852.htm (accessed May 26, 2017).

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