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Novel biomarkers may provide guide to personalized hepatitis C therapy

Date:
May 13, 2015
Source:
American Gastroenterological Association
Summary:
A simple blood test can be used to predict which chronic hepatitis C patients will respond to interferon-based therapy, according to a report. Hepatitis C chronically infects about 160 million people worldwide, and is a major cause of illness and death from hepatocellular carcinoma and end-stage liver disease.
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A simple blood test can be used to predict which chronic hepatitis C patients will respond to interferon-based therapy, according to a report in the May issue of Cellular and Molecular Gastroenterology and Hepatology, the basic science journal of the American Gastroenterological Association.

"While highly effective direct-acting antivirals have become the new standard of care for patients with hepatitis C, these treatments come with a hefty price tag," said lead study author Philipp Solbach, MD, from Hannover Medical School, Niedersachsen, Germany. "There may still be a role for the more affordable interferon-based therapies, and with this new information, we can better assess which patients will respond to this less-expensive treatment."

The researchers studied a cohort of HCV-infected patients who received interferon-based therapies and found that levels of oxidized low-density lipoprotein (LDL) in the blood predicted the patient's response to treatment. LDL, commonly known as "bad cholesterol," is easily identified through blood testing, and can be used as a surrogate marker for oxidized LDL.

Once oxidized LDL was established as a marker of treatment response, the authors studied hepatitis C transmission from cell to cell using an in vitro culture system. They found that oxidized LDL inhibited cell-to-cell spread, suggesting a mechanism underlying the relationship between oxidized LDL and a sustained viral response to interferon therapy.

"The study provides important information about the mechanism whereby HCV infection occurs," added Rebecca G. Wells, MD, associate editor of Cellular and Molecular Gastroenterology and Hepatology. "While direct-acting antivirals are coming to the forefront in HCV therapy, this study serves an important role in advancing our understanding of this complex virus."

This work raises the possibility that drugs that inhibit viral entry into cells may be useful add-ons to interferon therapy for hepatitis C virus; additionally, similar approaches may be effective for other chronic viral infections. Further studies testing entry-inhibiting drugs are needed.

Hepatitis C chronically infects about 160 million people worldwide, and is a major cause of illness and death from hepatocellular carcinoma and end-stage liver disease.


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Materials provided by American Gastroenterological Association. Note: Content may be edited for style and length.


Journal References:

  1. Philipp Solbach, Sandra Westhaus, Maximilian Deest, Eva Herrmann, Thomas Berg, Michael P. Manns, Sandra Ciesek, Christoph Sarrazin, Thomas von Hahn. Oxidized Low-Density Lipoprotein Is a Novel Predictor of Interferon Responsiveness in Chronic Hepatitis C Infection. CMGH Cellular and Molecular Gastroenterology and Hepatology, 2015; 1 (3): 285 DOI: 10.1016/j.jcmgh.2015.03.002
  2. Markus von Schaewen, Alexander Ploss. Novel Biomarkers Associated With the Outcome of Interferon-Based Hepatitis C Virus Therapy. CMGH Cellular and Molecular Gastroenterology and Hepatology, 2015; 1 (3): 257 DOI: 10.1016/j.jcmgh.2015.03.005

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American Gastroenterological Association. "Novel biomarkers may provide guide to personalized hepatitis C therapy." ScienceDaily. ScienceDaily, 13 May 2015. <www.sciencedaily.com/releases/2015/05/150513102906.htm>.
American Gastroenterological Association. (2015, May 13). Novel biomarkers may provide guide to personalized hepatitis C therapy. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/05/150513102906.htm
American Gastroenterological Association. "Novel biomarkers may provide guide to personalized hepatitis C therapy." ScienceDaily. www.sciencedaily.com/releases/2015/05/150513102906.htm (accessed May 26, 2017).

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