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Experimental Ebola treatment boosts survival in mice

Date:
May 20, 2015
Source:
American Chemical Society
Summary:
The number of new Ebola cases is tapering off, but the search for new treatments continues. Now, one research team has found potential drug candidates that successfully treated up to 90 percent of mice exposed to the Ebola virus.
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Scientists have found compounds that fought off Ebola infections in mice.
Credit: © bradcalkins / Fotolia

The number of new Ebola cases is tapering off, but the search for new treatments continues. Now, one research team has found potential drug candidates that successfully treated up to 90 percent of mice exposed to the Ebola virus. They report their findings in the journal ACS Infectious Diseases.

Bogdan A. Solaja, Rekha G. Panchal and colleagues note that the U.S. Food and Drug Administration has yet to approve any therapeutic drugs or vaccines against the Ebola virus that, since December 2013, has infected more than 25,000 people and taken the lives of more than 10,000. While some researchers are developing vaccines to prevent Ebola infections, others are focusing on treatments for the disease.

They are investigating a number of compounds, including existing malaria and flu drugs. Solaja's team has been looking into possible treatments by studying a class of small molecules called diazachrysenes, which they've found in lab tests to be non-toxic and effective against the most potent bacterial toxin, botulinum neurotoxin. They wanted to screen this family of compounds for possible anti-Ebola drug candidates.

The researchers narrowed down their search to a handful of diazachrysenes. In their study, 70 to 90 percent of the mice that received one of three of the experimental compounds survived infection and didn't show any obvious side effects.


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Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Života Selaković, Veronica Soloveva, Dima N. Gharaibeh, Jay Wells, Sandra Šegan, Rekha G. Panchal, Bogdan A. Šolaja. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases, 2015; 150504143047005 DOI: 10.1021/acsinfecdis.5b00028

Cite This Page:

American Chemical Society. "Experimental Ebola treatment boosts survival in mice." ScienceDaily. ScienceDaily, 20 May 2015. <www.sciencedaily.com/releases/2015/05/150520114305.htm>.
American Chemical Society. (2015, May 20). Experimental Ebola treatment boosts survival in mice. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/05/150520114305.htm
American Chemical Society. "Experimental Ebola treatment boosts survival in mice." ScienceDaily. www.sciencedaily.com/releases/2015/05/150520114305.htm (accessed May 23, 2017).

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