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Blood test for Alzheimer's one step closer

Date:
May 21, 2015
Source:
UNT Health Science Center
Summary:
A simple blood test to detect early Alzheimer's disease is a step closer to being used to screen older adults. Just as with blood tests for other diseases, such as diabetes, protocols must be established to make sure every lab performs the test exactly the same. Such guidelines are needed before FDA approval can be sought to use the test in a clinical setting. These such guidelines have just been released.
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Sid O'Bryant, PhD.
Credit: UNT Health Science Center

A simple blood test to detect early Alzheimer's disease is a step closer to being used to screen older adults.

Detailed standardized guidelines that are needed before a blood test could be used in practice have been published in Alzheimer's & Dementia. The guidelines establish protocols and reflect the continued efforts of an international working group that includes the University of North Texas Health Science Center.

"If we are ever going to get a blood test for Alzheimer's disease into the hands of primary care providers, we must have guidelines," said Sid O'Bryant, PhD, Interim Director of the Institute of Aging and Alzheimer's Disease Research at UNT Health Science Center.

The highly rigid guidelines will be used in research for blood-based biomarkers of Alzheimer's disease and will ensure every lab is following the same procedures when collecting blood, said Dr. O'Bryant, a member of the group and lead author of the paper.

"You can create a blood test in the lab, but if you don't have a systemized way for collecting the blood, the test will never go into practice," he said. "You'll have one lab doing it one way and another lab doing something different."

Dr. O'Bryant has worked for several years with representatives from across the United States, Australia, Germany, England and other countries to create the standards. Everything from the type of needle used to draw blood to the length of the storage time is specified in the guidelines.

Just as with blood tests for other diseases, such as diabetes, protocols must be established to make sure every lab performs the test exactly the same. Such guidelines are needed before FDA approval can be sought to use the test in a clinical setting.

"For UNTHSC, our next step is to take these blood guidelines and implement them into a clinical trial," Dr. O'Bryant said. "That's never been done before."


Story Source:

Materials provided by UNT Health Science Center. Note: Content may be edited for style and length.


Journal Reference:

  1. Christoph Laske, Hamid R. Sohrabi, Shaun M. Frost, Karmele López-de-Ipiña, Peter Garrard, Massimo Buscema, Justin Dauwels, Surjo R. Soekadar, Stephan Mueller, Christoph Linnemann, Stephanie A. Bridenbaugh, Yogesan Kanagasingam, Ralph N. Martins, Sid E. O'Bryant. Innovative diagnostic tools for early detection of Alzheimer's disease. Alzheimer's & Dementia, 2015; 11 (5): 561 DOI: 10.1016/j.jalz.2014.06.004

Cite This Page:

UNT Health Science Center. "Blood test for Alzheimer's one step closer." ScienceDaily. ScienceDaily, 21 May 2015. <www.sciencedaily.com/releases/2015/05/150521120922.htm>.
UNT Health Science Center. (2015, May 21). Blood test for Alzheimer's one step closer. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/05/150521120922.htm
UNT Health Science Center. "Blood test for Alzheimer's one step closer." ScienceDaily. www.sciencedaily.com/releases/2015/05/150521120922.htm (accessed May 26, 2017).

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