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Genetically elevated triglyceride level associated with protection against type 2 diabetes

Date:
May 28, 2015
Source:
PLOS
Summary:
Elevated plasma triglyceride level is considered a risk factor for type 2 diabetes, but new findings suggest that a genetically-elevated triglyceride level is associated with protection against type 2 diabetes. Researchers found that triglyceride-increasing alleles are associated with decreased type 2 diabetes incidence.
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Elevated plasma triglyceride level is considered a risk factor for type-2 diabetes, but new findings suggest that a genetically-elevated triglyceride level is associated with protection against type-2 diabetes. Yann Klimentidis, an Assistant Professor at the Mel and Enid Zuckerman College of Public Health at the University of Arizona, and colleagues found that triglyceride-increasing alleles are associated with decreased type-2 diabetes incidence. Their findings were published recently in PLOS Genetics.

Building on previous studies that hinted to the same association, Klimentidis and colleagues tested the relationship of triglyceride-associated genetic variants, collectively and individually, with type-2 diabetes incidence across three prospective cohort studies composed of European- and African-American participants.

Their findings across studies, racial groups, and statistical models consistently demonstrate that triglyceride-increasing alleles are associated with decreased type-2 diabetes incidence. The studied genes therefore appear to both increase triglyceride levels and decrease type-2 diabetes risk. Although no single gene appeared to be driving this trend, several, including a variant near the APOA1 gene, stood out as potentially interesting to this finding.

Although more work is needed to fully understand the physiological mechanisms that underlie these genetic associations and to further elucidate the causal relationship between triglycerides and type-2 diabetes, these findings are a promising start to our understanding of triglyceride-associated genes and their relationship with type-2 diabetes.


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Journal Reference:

  1. Yann C. Klimentidis, Akshay Chougule, Amit Arora, Alexis C. Frazier-Wood, Chiu-Hsieh Hsu. Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes. PLOS Genetics, 2015; 11 (5): e1005204 DOI: 10.1371/journal.pgen.1005204

Cite This Page:

PLOS. "Genetically elevated triglyceride level associated with protection against type 2 diabetes." ScienceDaily. ScienceDaily, 28 May 2015. <www.sciencedaily.com/releases/2015/05/150528142811.htm>.
PLOS. (2015, May 28). Genetically elevated triglyceride level associated with protection against type 2 diabetes. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/05/150528142811.htm
PLOS. "Genetically elevated triglyceride level associated with protection against type 2 diabetes." ScienceDaily. www.sciencedaily.com/releases/2015/05/150528142811.htm (accessed May 23, 2017).

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