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Kidney impairment decreases blood flow to the brain, boosting risk of brain disorders

Date:
August 6, 2015
Source:
American Society of Nephrology (ASN)
Summary:
Poor kidney function was strongly related to decreased blood flow to the brain, report researchers following a population-based study. Poor kidney function was linked to stroke and dementia most strongly in participants with decreased blood flow to the brain.
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Impaired kidney function may lead to decreased blood flow to the brain, and ultimately to the occurrence of stroke or dementia. The findings, which come from a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest that maintaining optimal kidney health can provide benefits to the brain.

Stroke and dementia are more common in patients with chronic kidney disease than in individuals in the general population, but it's unclear why. To investigate a potential kidney-brain link, M. Arfan Ikram, MD, PhD, Sanaz Sedaghat, MSc (Erasmus University Medical Center, in the Netherlands), and their colleagues examined information on 2645 participants in the population-based Rotterdam Study, looking at individuals' kidney function and blood flow to the brain.

The investigators found that poor kidney function was strongly related to decreased blood flow to the brain, or hypoperfusion. Also, poor kidney function was linked to stroke and dementia most strongly in participants with hypoperfusion. These findings were independent from known cardiovascular risk factors.

"Our findings provide a possible explanation linking kidney disease to brain disease," said Dr. Ikram. "Also, given that kidney disease and hypoperfusion of the brain are both possibly reversible, there might be an opportunity to explore how improving these conditions can ultimately reduce one's risk of developing brain disease." The study also shows that the kidney-brain link is not confined to patients with chronic kidney disease, but extends to persons from the general population without overt disease.


Story Source:

Materials provided by American Society of Nephrology (ASN). Note: Content may be edited for style and length.


Journal Reference:

  1. S. Sedaghat, M. W. Vernooij, E. Loehrer, F. U. S. Mattace-Raso, A. Hofman, A. van der Lugt, O. H. Franco, A. Dehghan, M. A. Ikram. Kidney Function and Cerebral Blood Flow: The Rotterdam Study. Journal of the American Society of Nephrology, 2015; DOI: 10.1681/ASN.2014111118

Cite This Page:

American Society of Nephrology (ASN). "Kidney impairment decreases blood flow to the brain, boosting risk of brain disorders." ScienceDaily. ScienceDaily, 6 August 2015. <www.sciencedaily.com/releases/2015/08/150806171242.htm>.
American Society of Nephrology (ASN). (2015, August 6). Kidney impairment decreases blood flow to the brain, boosting risk of brain disorders. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/08/150806171242.htm
American Society of Nephrology (ASN). "Kidney impairment decreases blood flow to the brain, boosting risk of brain disorders." ScienceDaily. www.sciencedaily.com/releases/2015/08/150806171242.htm (accessed May 26, 2017).

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